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Wednesday 5 February 2020
Eliquis (apixaban) is effective at treating and preventing blood clots. It's also effective at preventing stroke in people with nonvalvular atrial fibrillation, or nonvalvular AFib for short.
According to DailyMed, a website operated by the U.S. National Library of Medicine, Eliquis' efficacy and safety has been proven and analyzed in at least seven clinical studies.
A multinational, double-blind study called ARISTOTLE examined Eliquis' ability to reduce the risk of stroke and systemic embolism in people with nonvalvular AFib compared to that of warfarin. A total of 18,201 patients were randomized and followed over the course of the study.
The study aimed to determine whether a twice-daily 5mg dose of Eliquis was as effective as warfarin at preventing stroke and systemic embolism in people with nonvalvular AFib, as well as whether Eliquis was less likely to result in major bleeding or death from any cause.
After the study, researchers found that Eliquis was superior to warfarin at preventing stroke and systemic embolism. Of patients that took Eliquis, 212 experienced either a stroke (199 patients) or system embolism (15 patients) over a median time period of 89 weeks.
By comparison, of patients that took warfarin, 265 experienced either a stroke (250 patients) or systemic embolism (17 patients) over the same median time period.
What's more, Eliquis also showed significantly fewer instances of either major bleeding or death from any cause than warfarin.
The study also found that the time to first stroke or systemic embolism was about 24 months with Eliquis. With warfarin, that time was reduced to about 17 months.
The efficacy of Eliquis was generally not affected by weight, predicted risk of stroke, prior warfarin use, renal (kidney) impairment, geographic region or randomized aspirin use.
Three double-blind, multinational studies called ADVANCE-1, ADVANCE-2 and ADVANCE-3 aimed to determine Eliquis' efficacy for preventing deep vein thrombosis (DVT), nonfatal pulmonary embolism (PE) or death of any cause after hip or knee replacement surgery.
Across all three studies, 11,569 patients were randomized and followed.
In the ADVANCE-3 study, 5,407 patients undergoing elective hip replacement surgery were either given a twice-daily 2.5mg dose of Eliquis or a once-daily 40 mg dose of enoxaparin delivered subcutaneously.
Eliquis was administered 12 to 14 hours after surgery, and enoxaparin was administered nine to 15 hours before surgery. Treatment duration ranged from 32 to 38 days.
In the ADVANCE-2 study, 3,057 patients undergoing elective knee replacement surgery were given either twice-daily 2.5mg doses of Eliquis or a once-daily 40mg dose of enoxaparin delivered subcutaneously.
Eliquis was given 12 to 24 hours after surgery, and enoxaparin was given 9 to 15 hours before surgery. Treatment duration ranged from 10 to 14 days.
In the ADVANCE-1 study, 3,195 patients undergoing elective knee replacement surgery were given either twice-daily 2.5mg doses of Eliquis or 30mg doses of enoxaparin delivered subcutaneously every 12 hours.
Both Eliquis and enoxaparin were administered 12 to 24 hours after surgery. Treatment duration ranged from 10 to 14 days.
Two of the three studies, ADVANCE-3 and ADVANCE-2, found that Eliquis resulted in fewer instances of DVT, nonfatal PE or death of any cause than enoxaparin.
In ADVANCE-3, 1.39 percent of patients taking Eliquis experienced one of those events, compared to 3.86 percent of patients taking enoxaparin. In ADVANCE-2, 15.06 percent of patients taking Eliquis experienced one of those events, compared to 24.37 percent of patients taking enoxaparin.
The exception was ADVANCE-1, in which 8.99 percent of patients taking Eliquis experienced one of those events, compared to 8.85 percent of patients taking enoxaparin.
The efficacy of Eliquis was generally not affected by race, age, gender, body weight or renal (kidney) impairment.
As with all medications, it's imperative that you talk to your doctor to find out if Eliquis is right for you.
According to the Eliquis website, patients should not take Eliquis if they:
● Have an artificial heart valve.
● Have antiphospholipid syndrome (APS).
● Currently have certain types of abnormal bleeding.
● Have had a serious allergic reaction to Eliquis.
When discussing Eliquis with your doctor, be sure to tell them if you:
● Have kidney or liver problems.
● Have APS.
● Have ever had bleeding problems.
● Are pregnant or plan to become pregnant.
● Are breastfeeding or plan to breastfeed.
● Have any other medical condition.
If your doctor does decide that Eliquis is right for you, you can save money on your prescription by purchasing it from a reputable online pharmacy or pharmacy referral service.
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