Buy Xarelto (Rivaroxaban) - Brand & Generic

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What is Xarelto prescribed for?

Xarelto is used to treat or prevent deep vein thrombosis, a condition in which harmful blood clots form in the blood vessels of the legs. These blood clots can travel to the lungs and can become lodged in the blood vessels of the lungs, causing a condition called pulmonary embolism. After hip or knee replacement surgery, you are unable to walk. Due to the immobility, the risk of developing deep vein thrombosis or pulmonary embolism is increased. During this time, blood clots are most likely to form due to slowed blood flow. This medication is also used to lower the risk of stroke or a blood clot in people with a heart rhythm disorder called atrial fibrillation. Atrial fibrillation is when you have a heart rhythm that is rapid and irregular so your heart is unable to pump out blood efficiently enough and clots can form inside the atria.


How does Xarelto work?

Xarelto tablets contain the active ingredient Rivaroxaban, a type of drug that belongs to a class called anticoagulants. This medication blocks the activity of harmful clotting substances in the blood vessels. Xarelto (Rivaroxaban) comes in tablets for oral administration and can be purchased online at My Drug Center in the strengths of 10mg, 15mg, and 20mg. Rivaroxaban oral tablets may be used for short-term or long-term treatment. Your doctor will decide how long you should take this drug. Don’t stop taking it without talking with your doctor first.

Before taking your prescribed medication read all the instructions and paper work given to you by your pharmacist. Xarelto (Rivaroxaban) tablets are usually taken orally twice a day. Make sure you take Xarelto at the same time each day to create a routine for yourself and to ensure an even spread of medication in your system. Xarelto should taken on a regular basis to have optimal results. Your doctor may occasionally change your dose, use the medicine exactly as directed. You should continue taking this medication even if you feel well. 

You may take Xarelto with or without food depending on the strength. If you cannot swallow a tablet whole, crush and mix it with water, apple juice, or a spoonful of applesauce. Swallow the mixture right away without chewing. Do not save it for later use.

Xarelto (Rivaroxaban) may contain medical and non medical ingredients that could cause an allergic reaction. Consult with your doctor about any known allergies before taking Xarelto. Speak with your doctor about any known medical conditions relating to liver and kidney disease, bleeding problems, blood disorders, or stroke. Tell your doctor about any current medications or supplementation to avoid interactions with Xarelto.

Rivaroxaban can cause bleeding in the stomach, daily use of alcohol while taking this medication may increase the risk of this. To prevent unwanted bleeding with this medication, speak to your doctor regarding acceptable limits. You will also be at risk for external bleeding. Avoid contact sports and sharp objects while using this medication.

Do not stop taking Xarelto (Rivaroxaban) unless your doctor tells you to. Stopping suddenly can increase your risk of blood clot or stroke.

The most common side-effect of taking Xarelto (Rivaroxaban) is the increased likelihood of easy bruising or minor bleeding such as nosebleeds or bleeding gums. Try to avoid activities which may increase this such as contact sports and take care when shaving and brushing teeth.

Some other common side-effects are: skin rash, allergic reactions, fainting, nausea, and anemia.

If any side effects become unmanageable speak with your doctor or pharmacist for help in additional treatment. For any serious side effects speak with your doctor right away for further treatment options.

What is Xarelto used for?

Xarelto is approved for to help lower the risk of blood clots and their subsequent complications within a few different conditions. One of the most common uses of Xarelto is for the risk prevention of stroke and blood clotting in patients with atrial fibrillation (AFib), a heart rhythm disorder. This condition is characterized by a quivering or irregular heartbeat. Blood clots are a risk of this condition because when the heart beats irregularly, blood may not be pumped out properly which can result in the blood pooling together and forming a clot. Stroke is another risk factor of AFib because if the blood does pool and a blood clot does form, it can break off and travel to the brain, restrict blood flow, and result in a stroke.

Another condition Xarelto is commonly prescribed for is deep vein thrombosis (DVT) and pulmonary embolism (PE). When blood clots occur in the veins of the legs, it is known as deep vein thrombosis. It is a serious condition that causes swelling, throbbing pain, cramping pain, warm or red skin around the painful area, and swollen veins. It is a serious condition because if left untreated, the blood clot can travel and make its way into the lungs, blocking important blood vessels. When this occurs, it is known as pulmonary embolism. When important blood vessels in the lungs are blocked, the lungs can then become damaged due to the lack of blood flow, affecting not just the lungs but other organs as well, such as the heart. It can cause symptoms of shortness of breath, chest pain, anxiety, and lightheadedness. If the blood clot is big enough, or if there are multiple blood clots, the condition can become life-threatening.

Additionally, Xarelto may be prescribed to prevent blood clots in patients following hip or knee replacement surgery or those who are acutely ill. After the surgery, many patients become less active for up to several weeks. When you aren’t moving around as much and less muscle movement is occurring, blood flow becomes less rapid, travelling more slowly, and allowing a chance for the blood collect in the lower part of the body. This can then result in DVT which, as previously mentioned, can escalate further to PE, a more life threatening condition of the lungs.  Using Xarelto can help prevent these patients from developing a blood clot and risking further complications.

Who makes Xarelto?

Xarelto is made by Janssen Pharmaceutica. The company was founded in 1953 by Paul Janssen, with help from his father, Constant Janssen, who was a physician that aided in the distribution of pharmaceutical products for Richter, a Hungarian pharmaceutical company. Paul Janssen started Janssen Pharmaceutica on the third floor of his father’s company and a few years later, in 1955, Paul and his team had developed their first drug, Neomeritine (ambucetamide).  Eventually over time as the company grew, Janssen Pharmaceutica would go on to be purchased by Johnson and Johnson, an American corporation, in 1961. Between 1990 and 2004, Janssen Pharmaceutica expanded worldwide, growing in size by approximately 28,000 employees.


How long does Xarelto stay in your system?

When it comes to how long it takes a medication to clear from the system, it will always vary between individuals based on many personal factors. These factors may include age, weight, genetic make-up, other medications and medical conditions, and many others. Xarelto is especially sensitive to age; it typically clears out of the system of healthy patients aged 20-45 quicker than that of the elderly. You can find an estimate as to how long it may take to clear the system by multiplying the half-life of the medication by 5. The half-life measures how long it takes for the medication to clear by half. In the elderly, the half-live will range from 11-13 hours therefore it may take up to 65 hours (or 2.7 days) to clear the system in the elderly. Other patients, such as those between the ages of 20-45, may be able to expect the medication to clear after 45 hours (or 1.9 days) with the half-life ranging around 5-9 hours.


Why take Xarelto with food?

Depending on what dose you have been prescribed, you may or may not have to take this medication with food.  For the 10mg dose, you may take it with or without food, as directed by your doctor. However, the 15 and 20 mg dosages should be taken with food. Taking Xarelto on an empty stomach can decrease the bioavailability of the drug. To give you a better understanding, here are the results of a clinic trial to evaluate the impact of food consumption on the pharmacokinetics of Xarelto:

-          The oral bioavailability of the 10mg tablet was seen almost complete in both those who were fed and fasting before the dose.

-          The oral availability of the 20mg tablet was seen at 66% in those who were fasting and nearly complete for those were fed.

-          The oral availability can be increased in both the 15 and 20 mg tablet by taking the dose with food.

The bioavailability of a medication measures how much of the drug reaches systemic circulation. When oral availability is complete, it is 100% absorbed by the body. In order for drugs to be effective, they must first be absorbed into the blood stream. So since food has been shown to reduce the bioavailability of Xarelto, it in turn reduces the amount of the drug absorbed by the body, and can reduce the overall effectiveness of the drug. The clinical trial results were posted by the American College of Clinical Pharmacology.


When will Xarelto go generic?

It is hard to say exactly when a generic for Xarelto will become available. When a manufacture develops a brand-new medication, there are certain laws that can be set in place to prevent generic manufacturers from developing their own form of the medication. This grants the brand-manufacturer marketing exclusivity for many years which can help make up for the billions of dollars it costs to research, develop, and market the new drug. Xarelto has been protected by these laws since 2007 and doesn’t set to expire until 2024, so we have a few more years to go before generic manufacturers will be able to market their own generic forms of Xarelto. However, you don’t have to wait that long for reasonably priced Xarelto. You can purchase the brand-name medication made by Janssen Pharmaceutica for generic-like prices when you purchase internationally through My Drug Center. We have a starting price of $89.00 when you buy a supply of 30 tablets.


What are the side effects of Xarelto?

Some of the most common side effects of this medication are becoming easily bruised or minor bleeding (such as a nose bleed or bleeding gums). While these are the most common side effects, they are not the only ones that are listed. Be aware that there are many different possible side effects that may occur. Also keep in mind that side effects are a normal response of the body when taking a new medication and should not alarm you. If they do become unmanageable or do not subside with time, consult with your doctor.


 Why is Xarelto so expensive?

Xarelto may be expensive for a few different reasons. The biggest one may be that it was only approved for medical use in 2011, making it a newer medication. Newer medications are usually expensive due to the high cost of researching, developing, and then marketing the new medication. Throughout 4 different phases of clinical research, it takes roughly 10 years to get from the point of initial discovery of the drug to placing it on the market for sale. On average, it costs around $1-2 billion to research and develop a successful medication. So it wouldn’t be a surprise that Janssen Pharmaceutica has placed a high cost on Xarelto, considering the amount of money and time it likely took to develop it. Additionally, since it is a newer medication, there are no competing generics due to patent and exclusivity laws, allowing Janssen Pharmaceutica to market Xarelto for any given price without fear of losing patients to competitors. In addition to that, Medicare has placed Xarelto on tier 3 of their formulary, making it one of the more expensive tier medications. Keep in mind, not all patients have the advantage of medicare, so many patients are still stuck paying for the medication completely out of pocket. Furthermore, many patients need to buy this medication each month, with a high cost and possibly no medicare, purchasing Xarelto each month can become very costly. All of these factors may contribute to the high cost of Xarelto, but these factors are not universal. This means that in other areas of the world, Xarelto can be purchased for a more reasonable price. You may wonder how one can purchase a medication internationally; and though it may sounds difficult, it’s actually quite easy. Online Canadian pharmacies like My Drug Center make it possible for you to order medication internationally from the comfort of your own home and have it shipped directly to your front door for an easy and affordable way to fill your prescription. Order today by calling our toll free number of 1-877-385-8998; keep in mind, you will be required to present a valid prescription.


How long has Xarelto been on the market?

Xarelto has been approved for prevention of deep vein thrombosis in patients undergoing surgery since 2011. In 2012, the approved uses for Xarelto were expanded to treat and reduce recurrence of blood clots and in 2017, were approved to market a 10 mg tablet. In 2018, another approved use was added; reducing the risk of major cardiovascular events in patients with chronic coronary artery disease or peripheral artery disease, and again in 2019 for the prevention of blood clots in acutely ill medical patients.

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