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How Jardiance Helps Prevent Heart Failure

Monday 29 January 2024
5 minute(s) read

Table of Contents

I. What is Jardiance?

II. How Does Jardiance Prevent Heart Failure?

III. Jardiance Safety and Side Effects

IV. Accessing Your Jardiance Prescription Affordably

Over the past decade, Jardiance has been a breakthrough medication for type 2 diabetes. During that time, it’s also shown to reduce the risk and effects of many cardiovascular issues, including heart failure, making it a dually beneficial option for many patients.

In this article, we’ll explore the specific benefits of Jardiance for heart failure, its safety history and side effects, and how to access your Jardiance prescription safely and affordably.

Quick Takeaways:

  • Jardiance is classified as an SGLT-2 inhibitor, which helps lower blood sugar in patients with type 2 diabetes.
  • Over time, Jardiance has shown beneficial health effects for those with cardiovascular issues, including heart failure.
  • It can also facilitate blood pressure and body weight reduction, and relieve arterial stiffness.
  • Canadian pharmacies are a safe and affordable option for ordering Jardiance prescriptions at a lower cost.

What is Jardiance?

Jardiance is a medication primarily used for the treatment of type 2 diabetes. It belongs to a class known as Sodium-Glucose Co-Transporter 2 (SGLT-2) inhibitors that work by preventing the kidneys from reabsorbing glucose back into the blood, which leads to the excretion of excess glucose through urine and lowers blood sugar levels.

Graphic showing Jardiance’s mechanism of action in lowering blood sugar


Jardiance was first approved for medical use in the United States in 2014, and since its introduction, it has become a widely prescribed medication for adults managing type 2 diabetes. Over time, Jardiance has also been recognized for its role in heart health, particularly in reducing the risk of cardiovascular death and hospitalization for heart failure in adults.

How Does Jardiance Prevent Heart Failure?

While Jardiance's mechanism of action was initially leveraged for lowering blood sugar levels in diabetes patients, it also has a beneficial impact on heart health. By promoting the excretion of glucose, Jardiance inadvertently reduces the overall blood volume and decreases the sodium content in the body.

This reduction eases the workload on the heart, which is particularly advantageous for individuals with heart failure, where the heart's ability to pump blood is compromised.

Additional heart benefits Jardiance can facilitate include reductions in blood pressure and body weight, improvements in arterial stiffness, and a decrease in the risk of heart failure. Because people with type 2 diabetes often deal with these types of heart risks, Jardiance offers them dual benefits.

The effectiveness of Jardiance in preventing heart failure is backed by substantial clinical evidence. Key studies such as the EMPA-REG OUTCOME demonstrated that patients with type 2 diabetes treated with Jardiance had a significantly lower risk of heart failure hospitalization and cardiovascular death when compared to those on a placebo. [2]

The EMPEROR-Reduced trial expanded these findings, showing that Jardiance reduced the risk of cardiovascular death and heart failure hospitalization in patients with heart failure with reduced ejection fraction (HFrEF), irrespective of their diabetes status. [3]

The transition of Jardiance from a diabetes-specific medication to a broader cardiovascular therapeutic agent marks a significant advancement in the treatment of heart failure.

Jardiance Safety and Side Effects

Jardiance, while effective for type 2 diabetes and heart failure prevention, has a safety profile that necessitates awareness of its side effects and usage precautions. Common side effects include urinary tract and yeast infections, driven by increased glucose in urine.

Patients might also experience dehydration, dizziness, or lightheadedness, often related to its diuretic effect. More serious, though rare, side effects include diabetic ketoacidosis, severe urinary tract infections, and Fournier's gangrene, a serious bacterial infection. These require immediate medical attention if symptoms like abdominal pain, nausea, or genital area swelling occur.

Jardiance is not recommended for patients with severe kidney issues or type 1 diabetes due to increased risks, including ketoacidosis. It's advised to be used cautiously in elderly patients or those with kidney impairments, necessitating possible dosage adjustments. The typical starting dose for Jardiance is 10 mg daily, potentially increasing to 25 mg based on individual response and kidney function.

Regular monitoring of blood sugar levels is crucial, especially for those on other diabetes medications, to avoid hypoglycemia, and patients should always follow their healthcare provider's instructions regarding dosage and report any concerning symptoms promptly.

Accessing Your Jardiance Prescription Affordably

Canadian pharmacies are a helpful option for those seeking Jardiance at a more affordable price. Known for offering significant savings on medications, Canadian pharmacies present an avenue for patients who want to save on their prescriptions without sacrificing quality or reliability. The benefits are manifold:

  • Cost Savings: Canadian pharmacies often provide medications at prices much lower than those in the U.S. At My Drug Center, for example, patients can save up to 80% on their prescriptions, including Jardiance.
  • Certified and Safe: These pharmacies are typically certified by organizations like the Canadian International Pharmacy Association (CIPA), ensuring they meet safety and quality standards. This certification is crucial for ensuring that you receive genuine and safe medications.
  • Simple Ordering Process: Ordering from Canadian pharmacies is straightforward, often allowing you to place orders online or over the phone. This convenience is especially beneficial for those who require regular medication refills, live in rural areas, or have mobility limitations.
  • Consultation Services: Many Canadian pharmacies offer pharmacist consultations, providing an added layer of service to ensure that your medication needs are appropriately met.
  • Delivery Options: With options for home delivery, Canadian pharmacies can send your Jardiance prescription directly to your doorstep, adding convenience to affordability.

Importing Canadian prescription drugs to the U.S. is safe and legal, but there are some regulations that must be followed. All orders require a valid prescription from a licensed U.S. healthcare provider, drugs must be approved for safety by the FDA, and some state-level laws may also apply.

By opting for Canadian pharmacies, patients in need of Jardiance for heart failure can manage their health effectively without the burden of high medication costs.

My Drug Center helps thousands of people save on their prescriptions every year, and provides a wide variety of popular prescription medications, including Jardiance. Learn more here about how to order.

The information in the article is not meant to be used for treatment or diagnosis. It is designed for general awareness and for information purposes only. Always consult a medical professional for your specific healthcare needs.