My Drug Center

What Is the Safest Drug for Erectile Dysfunction?

Friday 8 September 2023
Erectile Dysfunction
6 minute(s) read

Table of Contents

I. Understanding Erectile Dysfunction and Its Impact

II. Top Four Erectile Dysfunction Medications

i. Sildenafil (Viagra)

ii. Tadalafil (Cialis)

iii. Vardenafil

iv. Avanafil (Stendra)

III. Other Considerations and Individual Factors

IV. Non-Medical Approaches

V. So: What is the Safest Drug for Erectile Dysfunction?

What is the safest drug for erectile dysfunction? If you’re one of the hundreds of millions of men dealing with ED, it’s a question you’ve probably asked before.

In this guide, we’ll give you the answer (and more).

The sections that follow will provide an overview of the top four prescription drugs for ED on the market today and outline how to choose an ED medication and treatment plan that works for you.

Quick Takeaways

  • By age 40, more than one-third of men deal with some level of erectile dysfunction.
  • The top four ED medications on the market are sildenafil (Viagra), tadalafil (Cialis), vardenafil, and avanafil (Stendra).
  • ED medications must be evaluated on important factors like how long their effects take to work, the length of effectiveness, and known side effects.
  • Sildenafil (Viagra) is often the first ED medication doctors prescribe because of its length of time on the market and proven effectiveness.
  • Healthy lifestyle habits like quitting smoking, limiting alcohol, and diet and exercise can help to improve ED function in conjunction with medication.

Understanding Erectile Dysfunction and Its Impact

Erectile dysfunction (ED) is medically defined as the inability to achieve or maintain an erection sufficient for sexual activity. But the impact of ED on men dealing with the condition goes beyond just its physical symptoms—it can also have mental and emotional implications that decrease self-esteem, put strain on relationships, and trigger a cycle of anxiety and performance pressure.

Further, while ED prevalence does increase with age, its impact on men not yet middle-aged is higher than most think. By age 40, more than a third of men are dealing with some level of ED. [1]

Bar chart showing the prevalence of ED by age group, including more than a third of men deal with some level of ED by age 40


The distressing nature of ED is underscored by its potential to magnify preexisting mental health issues, such as depression and anxiety. The inability to engage in a fundamental aspect of intimacy can create feelings of inadequacy and frustration, leading to a vicious cycle where the psychological strain further exacerbates the condition.

It’s essential for men with ED to know that effective treatment is available for them and how to evaluate which ED drug is safest for them. Doing so sooner rather than later prevents ED symptoms from spiraling to the point that they negatively impact overall quality of life.

Top Four Erectile Dysfunction Medications

Sildenafil (Viagra)

Sildenafil, commonly known by its brand name Viagra, was a groundbreaking discovery in the field of ED treatment. Approved by the U.S. Food and Drug Administration (FDA) in 1998, sildenafil works by enhancing the effects of nitric oxide, a natural chemical that relaxes muscles in the penis and increases blood flow.

Today, it’s the most commonly prescribed and taken erectile dysfunction drug on the market. Today, it’s been used by more than 30 million men worldwide. [2]

But, like all medications, it does have some potential side effects. These include:

  • Headaches
  • Flushing
  • Indigestion
  • Vision disturbances (rare)

That said, sildenafil is generally considered safe for most men.

Tadalafil (Cialis)

Tadalafil, marketed as Cialis, is another popular ED medication. What sets it apart is its longer duration of action—up to 36 hours—which has earned it the nickname "the weekend pill."

Like sildenafil, tadalafil enhances nitric oxide effects. It comes in various dosages, including a daily low-dose option. Side effects are similar to sildenafil and may include headaches, indigestion, muscle aches, and back pain.

Tadalafil also carries a potential risk of interacting with nitrates, so a thorough medical evaluation is crucial before use.


Vardenafil, formerly sold under the brand name Levitra, is closely related to sildenafil in terms of its mechanism of action. It's known for its rapid onset of action and is effective for many men with ED.

Common side effects include headaches, flushing, and nasal congestion. As with the other medications, it's important to avoid vardenafil if taking nitrates or alpha-blockers, which are used to treat conditions like hypertension and benign prostatic hyperplasia.

Avanafil (Stendra)

Avanafil, marketed as Stendra, is the newest medication among the top ED drugs. It boasts a rapid onset of action and potentially fewer side effects than its counterparts thanks to a newer formula.

Avanafil's safety profile is similar to the other medications, with common side effects including headaches, flushing, and nasal congestion. Like the rest, it's not recommended for use with nitrates due to potential interactions.

Other Considerations and Individual Factors

When determining the safest ED medication, several factors come into play. It's important to consider your overall health, existing medical conditions, and any medications you're currently taking. A consultation with a healthcare provider is crucial to ensure that the chosen medication doesn't interact negatively with other drugs or exacerbate underlying health issues.

Furthermore, personal preferences and lifestyle also play a role. Some men may prefer the flexibility of tadalafil's extended duration, while others might prioritize a rapid onset of action offered by avanafil. In many cases, men choose sildenafil because of its time on the market and long-proven effectiveness.

Open communication with a healthcare provider can help you tailor your treatment plan to individual lifestyle and medical needs.

Non-Medical Approaches

You can enhance the effects of ED medications by making lifestyle changes as well. Quitting smoking, reducing alcohol consumption, managing stress, and maintaining a healthy weight can all contribute to better erectile function.

Regular exercise has also been shown to improve ED in some cases by enhancing cardiovascular health and boosting overall well-being.

So: What is the Safest Drug for Erectile Dysfunction?

All of the erectile dysfunction medications we covered in this guide are considered safe for most men. In most cases, sildenafil is the medication prescribed first because of physician familiarity with its effects, its extended time on the market, and its established effectiveness in treating ED. Men also recognize the brand name of Viagra and thus may feel more comfortable taking it.

From those perspectives, sildenafil or Viagra may be considered the safest drug for erectile dysfunction. The truth, however, is that every individual and case of ED is different. The best way to determine the safest ED drug for you is to do it in conjunction with your physician.

Your doctor can guide you toward the most suitable ED medication option and ensure a treatment plan that prioritizes your well-being and sexual health.

Moreover, embracing a healthy lifestyle can complement your medication and contribute to long-term improvements in erectile function. Remember, the path to regaining sexual confidence begins by making informed decisions, having open conversations with your healthcare provider, and staying attuned to your individual health and lifestyle needs.

My Drug Center offers safe, affordable ordering and home delivery for Viagra and other leading ED medications. Visit our website to learn more.

The information in the article is not meant to be used for treatment or diagnosis. It is designed for general awareness and for information purposes only. Always consult a medical professional for your specific healthcare needs.