How Effective is Advair HFA?

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Advair HFA (fluticasone/salmeterol) is an effective treatment for asthma.

Its efficacy has been observed in numerous clinical studies. As reported by DailyMed, a website operated by the U.S. National Library of Medicine, there have been eight clinical safety and efficacy trials on Advair HFA.

Advair HFA Efficacy Compared to Either Fluticasone or Salmeterol Alone

To compare the efficacy of Advair HFA to the efficacy of either fluticasone or salmeterol alone, four double-blind, parallel-group clinical trials were conducted on 1,517 adults and adolescents over the age of 12.

All four of those trials used metered-dose inhaler treatments administered via inhalation aerosols given as two inhalations twice daily.

In each trial, the efficacy of Advair HFA was greater than the efficacy of either fluticasone or salmeterol alone.

On an asthma symptom scale from zero to five, patients taking Advair HFA 45/21 experienced a one-point reduction in symptoms.

Patients taking fluticasone 44mcg experienced a 0.3 reduction, patients taking salmeterol 21mcg experienced a 0.4 percent reduction and patients taking a placebo experienced no reduction.

Advair HFA Efficacy in Onset of Action and Asthma Control

Advair HFA's efficacy in onset of action and progression of improvement in asthma control was measured in two placebo-controlled trials and one active-controlled trial.

After the first dose, the median time to onset of clinically significant bronchodilation (opening of the airways) in most subjects was 30 to 60 minutes. This was true for Advair HFA 45/21, fluticasone 44mcg, salmeterol 21mcg and a placebo.

Advair HFA, however, provided the highest level of sustained asthma control over a period of 12 hours.

On the first day of treatment, Advair HFA provided slightly more sustained asthma control than salmeterol.

By the 12th week of treatment, though, Advair HFA provided significantly more sustained asthma control than either fluticasone, salmeterol or a placebo.

Is Advair HFA Right for You?

Always talk to your doctor to find out if Advair HFA is a suitable asthma medication for you.

 As per the Advair HFA website, be sure to tell your doctor if you have: 

      Heart problems

      High blood pressure


      Thyroid problems


      Liver problems


      An immune system problem

      Eye problems

      A milk protein allergy

      Any type of viral, bacterial or fungal infection

Also tell your doctor if you are exposed to chickenpox or measles, are breastfeeding or are pregnant or plan to become pregnant. Make sure you follow the specific shelf life of your Advair HFA inhaler to guarantee it’s effectiveness. 

If your doctor decides to prescribe you with Advair HFA, you can save money on your inhalers by purchasing them from a trustworthy online pharmacy or pharmacy referral service.


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