Myrbetriq (mirabegron) is a prescription medication used to treat certain bladder problems. It is available in two forms: extended-release tablets and granules. The tablets are taken orally, while the granules come in a liquid suspension that is also taken orally.

The FDA approved Myrbetriq in 2012 for the treatment of two conditions:

• Overactive bladder (OAB) in adults: OAB occurs when the detrusor muscle in the bladder contracts too often or without warning. This can cause urinary frequency, urgency, or incontinence. Myrbetriq helps alleviate OAB symptoms by relaxing the detrusor muscle, allowing the bladder to store more urine. It can be taken alone or in combination with another medication called solifenacin succinate.

• Neurogenic detrusor overactivity (NDO) in children ages three years and older: NDO refers to an overactive bladder caused by nerve problems, such as multiple sclerosis or spinal cord injury. Children with NDO experience urinary frequency, urgency, and incontinence.

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Myrbetriq relaxes the detrusor muscle in your bladder, which is the muscle responsible for signaling your bladder to empty. When this muscle is overactive, it can cause symptoms like the sudden urge to urinate, frequent urination, or loss of bladder control.

Myrbetriq belongs to a class of drugs called beta-3 adrenoceptor agonists. It works by activating beta-3 adrenergic receptors in the detrusor muscle, causing it to relax. This helps increase the amount of urine your bladder can hold and reduces overactive bladder symptoms.

Myrbetriq comes in two different formulations: extended-release tablets and extended-release oral suspension. Each formulation comes in different dosages:

• Extended-release tablets: 25 mg and 50 mg
• Extended-release oral suspension: 8 mg/mL

Please note that the tablets and oral suspension are different products, and the dosages cannot be interchanged. If you would like to switch between the formulations, it’s essential to talk to your doctor first.

The dosage depends on whether Myrbetriq is being used for an adult or a child, as well as kidney and liver function. We’ve included the general dosage recommendations from the FDA, but your personal dosage will be determined by your doctor:

• Adults with overactive bladder (OAB): Start with 25 mg taken by mouth once daily for 4 to 8 weeks. After this time, your doctor may increase the dose to 50 mg once daily.

• Children aged three and older weighing less than 35 kg with neurogenic detrusor overactivity (NDO): Myrbetriq granules may be prescribed, with the dosage based on your child's weight. Your doctor will determine the appropriate dosage.

• Children aged three and older weighing more than 35 kg with NDO: Either Myrbetriq tablets or granules may be prescribed. For tablets, start with 25 mg taken by mouth once daily for 4 to 8 weeks, then your doctor may increase to 50 mg once daily. For granules, start with 6 mL taken by mouth once daily for 4 to 8 weeks, then increase to a maximum of 10 mL once daily.

Myrbetriq may cause side effects in some people. It's important to be aware of potential side effects and contact your doctor if any persist or cause concern.

Common side effects include:

• High blood pressure
• Nasopharyngitis
• Urinary tract infection (UTI)
• Headache

Serious side effects may also occur with Myrbetriq. Contact your doctor immediately if you experience the following:

• Inability to empty your bladder: Myrbetriq may increase the risk of urinary retention, especially if you have an obstruction or are on other medicines for an overactive bladder. Contact your doctor right away if you are unable to empty your bladder.

• Angioedema: Myrbetriq may cause an allergic reaction with swelling of the lips, face, tongue, or throat and difficulty breathing. If this occurs, stop taking Myrbetriq and go to the nearest emergency room immediately.

What is Myrbetriq used for?

Myrbetriq is an FDA-approved prescription medicine for certain cases of overactive bladder. It treats urinary urgency, frequency, and leakage due to overactive bladder in adults and neurogenic detrusor overactivity (NDO) in children three years and older.

How long does it take for Myrbetriq to work?

In clinical studies, many participants experienced an improvement in symptoms after four to eight weeks. However, some participants experienced relief after 12 weeks.

How do I take Myrbetriq?

Take Myrbetriq once daily with or without food. It’s important to take your dosage consistently and not just when symptoms are bothering you.