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Zyclara Cream is a medication made up of an immune response modifier called imiquimod. We carry the brand choice of this medication in 3.75%. 

This medication is used on the skin, for conditions such as genital or anal warts and actinic keratoses (AK). Actinic keratoses is caused by excess sun exposure and causes a precancerous growth on the skin. If this condition goes untreated, the complications include actinic cheilitis, basal cell carcinoma, melanoma and rare forms of skin cancer (like Merkel cell carcinoma).

Zyclara Cream (Imiquimod) is effective at treating certain skin conditions because it is able to increase the effect of the immune system; the body’s defense mechanism against disease and infection).

Use this medication only the way your doctor has prescribed it to you. Follow all directions very carefully; they can usually be found on your prescription label if you forget. Do not use this medication for longer than recommended. Keep out of your mouth, eyes, and nose. Do not put this medication inside of your vagina or anus, or on sunburned or healthy skin.

Use this medication at bedtime. Ensure you are washing your hands before and after each use. Clean the affected area before applying the medication. Apply a thin layer and gently rub it in. After applying, do not shower, swim, or bathe.


Do not use Zyclara Cream (imiquimod)

You should not use this medication if you are allergic to imiquimod, if your skin has not healed from other care or surgery, or if you are using another drug also containing imiquimod.

Dose adjustment or special precautions may be required

Tell your doctor about all existing medical conditions to ensure this medication is safe for you to use.


Avoid sexual contact if this medication is being applied to genital areas. Non-hormonal birth controls methods may become less effective if used with this cream.

You should only use this medication when pregnant if you clearly need the medication. Discuss the risks and benefits with your doctor.

It is not known if this medication will pass into breast milk or if it will harm a nursing infant. Speak with your doctor if you are breast feeding.

Side Effects

Common side effects of Zyclara Cream (imiquimod) may include:

Change in color of skin. This may not go back to normal. Headache. Upset stomach. Feeling tired or weak. Signs of a common cold. Sinus pain.

The above side effects should not alarm you.

Serious side effects of Zyclara Cream (imiquimod) may include:

Flu-like signs. These include headache, weakness, fever, shakes, aches, pains, and sweating. Bleeding. Swollen gland.

For genital or perianal warts:

Vaginal pain or swelling. Trouble passing urine.

allergic reaction: sneezing and an itchy, runny or blocked nose (allergic rhinitis), itchy, red, or watering eyes (conjunctivitis), wheezing, chest tightness, shortness of breath, cough, a raised itchy, red rash (hives) or swollen lips, tongue, eyes or face. (For both AK and genital or perianal wart treatment)

If you have any of the above side effects or signs of complications, contact your doctor right away.

Please note this is not a complete list of side effects. Not everyone experiences side effects; they are not guaranteed. If you do have side effects and they become unmanageable, consult your doctor about alternate medications.


Can children use this medication?

For the treatment of AK, the safety and effectiveness in patients younger than 18 have not been established. However, this medication may be used in those who are at least 12 years old for the treatment of genital and perianal warts.

Will this medication cure my human papillomavirus (HPV)?

This medication will only help eliminate warts that are a result of the virus, but cannot remove the virus (human papillomavirus) from your body.

What should I avoid while using this medication?

Avoid sun exposure during treatment. This medication may cause you to become more sensitive to light. When outside in the sun, you should wear sunscreen and sun protective clothing.

Can I drink alcohol on this medication?

You should try to limit your alcohol consumption during treatment. Alcohol (and marijuana), when mixed with imiquimod, can make you dizzy or dizzier if the side effect was already present. Avoid doing activities that require your full attention.

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