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Zofran ODT is an orally disintegrating tablet made up of a 5HT3 receptor antagonist called ondansetron. We carry the brand choice and the generic alternative of this medication in 4mg and 8mg. 

Zofran ODT is prescribed to patients experiencing nausea and vomiting caused by surgery, cancer chemotherapy, or radiation treatment. Chemotherapy and radiation therapy are methods of killing cancer cells, however, they also kill healthy cells in the process. The affected (healthy) cells are usually located in the protective lining of the mouth and digestive tract which then causes irritation leading to symptoms of nausea and vomiting. These symptoms occur after surgery usually due to the anesthesia, but may also be caused by pain or discomfort.

Zofran ODT (ondansetron) is effective at treating nausea and vomiting in post surgery, cancer chemotherapy, or radiation treatment because it is able to block the actions of the chemicals in the body that cause you to have these reactions (nausea and vomiting).

Your doctor will tell you before prescribing you Zofran ODT (ondansetron) exactly how to take this medication. Follow his or her directions, they can usually be found on the prescription label if you forget.

Zofran ODT is taken with or without food, usually at the start of your surgery, chemotherapy or radiation treatment. It should not be swallowed whole; to properly use this medication, allow it to dissolve in your mouth while swallowing several times. Do not chew, crush, break, or swallow this tablet whole.

Ensure the lid is tightly closed when not in use. Avoid keeping this medication in an area where it risks becoming wet or hot. Keep out of reach of children.


Do not use Zofran ODT (ondansetron)

Zofran ODT should not be used by those who are allergic to ondansetron or other similar medicines (dolasetron, granisetron, palonosetron), or if you also use apomorphine (Apokyn).

This medication is not approved for those under the age of 4 years old.

Dose adjustment or special precautions may be required

To ensure this medication is safe for you, tell your doctor if you have liver disease, an electrolyte imbalance, congestive heart failure, slow heartbeats, a personal or family history of long QT syndrome, or a blockage in your digestive tract (stomach or intestines).

Tell your doctor if you have PKU-phenylketonuria.


This medication is not expected to harm an unborn baby; however, it is still recommended you tell your doctor if you are pregnant or plan on becoming pregnant.

It is not known if this medication will pass into breast milk or if it will harm a nursing infant. Tell your doctor if you are breast feeding.

Side Effects

Common side effects of Zofran ODT (ondansetron) may include:

diarrhea or constipation; headache; drowsiness; or tired feeling.

The above side effects should not alarm you.

Serious side effects of Zofran ODT (ondansetron) may include:

severe constipation, stomach pain, or bloating; headache with chest pain and severe dizziness, fainting, fast or pounding heartbeats; fast or pounding heartbeats; jaundice (yellowing of the skin or eyes); blurred vision or temporary vision loss (lasting from only a few minutes to several hours); or

high levels of serotonin in the body: agitation, hallucinations, fever, fast heart rate, overactive reflexes, nausea, vomiting, diarrhea, loss of coordination, fainting.

If you have any of the above side effects or signs, contact your doctor right away.

Please note this is not a complete list of side effects. Not everyone experiences side effects; they are not guaranteed. If you do have side effects and they become unmanageable, consult your doctor about alternate medications.


What is Ondansetron ODT?

Ondansetron ODT is a 5-HT3 antagonist sold as the brand-name prescription medication Zofran ODT. It comes in the form of an orally disintegrating tablet (ODT) for oral administration in 4 or 8 mg. Tablets are taken by mouth, metabolized by the liver, and excreted by the kidneys with a half-life of about 5.7 hours. It is available only with a valid prescription and can be purchased as a generic alternative, sold as Ondansetron ODT. We carry both forms (brand and generic) at My Drug Center for an affordable cost.


What is Ondansetron used for?

Ondansetron is used either alone or with other medications to help prevent symptoms of nausea or vomiting following certain types of cancer treatments. Chemotherapy and radiation therapy are two cancer treatments which may cause these symptoms to occur. Additionally, Ondansetron may be used to help prevent nausea and vomiting as a result of cancer medications, pregnancy (when vomiting is severe), acute gastroenteritis (in children), and after surgery.


How does Ondansetron work?

Serotonin, a natural chemical in our bodies you’ve likely heard about before, is partly responsible for feelings of nausea. Enterochromaffin cells (located in the small intestine) respond to chemotherapeutic agents by releasing serotonin. The serotonin in turn may stimulate certain receptors that initiate the vomiting reflex resulting in nausea and/or vomiting. Ondansetron works by blocking the serotonin and preventing the vomiting reflex from being initiated.


How often can I take Zofran ODT?

The frequency in which you can take Zofran ODT will depend on quite a few factors, especially on the indication of treatment and age. For radiation therapy in adults, it will depend on if it is a total body irradiation, single high-dose fraction radiotherapy for the abdomen, or a daily fractionated radiotherapy for the abdomen.  Chemotherapy will depend on if its moderate or highly emetogenic. For children, it depends if you are between the ages of 4-11 and 12-17 (weight may also be a factor). Only your doctor will be able to determine how often you can take Zofran ODT, there are many other factors not listed here that may also determine how often you can take the medication. For multi-dosing, the first dose is usually taken before the start of the cancer treatment with doses following every 8-12 hours after the initial dose; for children, a second dose is usually taken 4 and 8 hours after the initial dose. Treatment using Zofran ODT is commonly continued for 1-2 days following the cancer treatment.


How long does Zofran take to work?

The exact length of time it takes for the onset of effects to begin will typically vary between each individual. Zofran (ODT) generally begins to work within 30 minutes of administration with peak effects occurring after 2 hours. Certain factors may influence the amount of time it takes to work, so remember to take this medication exactly as prescribed and ask your doctor about any questions you may have before starting treatment.


How long does Zofran last in your system?

Zofran (ODT) will remain in the system for up to 28.5 hours (a little over one full day), however; the exact amount of time may vary between each individual based off certain factors such as age, weight, and gender. It takes about 5.7 hours for half of the medication to clear the system.


What are the side effects of Ondansetron?

Some common side effects of Ondansetron include diarrhea or constipation, headache, tired feeling, or drowsiness. All of these side effects are a normal response of the body when taking a new medication and should not alarm you. However, if they worsen or do not go away over time, you should notify your doctor. Keep in mind, not all side effects have been listed here.


Where can I buy Zofran ODT?

You can purchase the brand-name product as well as the generic alternative from the comfort of your own home at My Drug Center. Online Canadian Pharmacy services like My Drug Center make it possible for you to order medication internationally from places around the world where the medication is sold for a lower cost compared to United States pharmacies. So how much is Zofran ODT at My Drug Center? My Drug Center offers you Ondansetron (Zofran ODT) for $123.00 when you buy a supply of 100 (8mg) tablets; in the United States, 100 (8mg) tablets would cost you 4 times as much. You can place an order today and save on your medication(s) by calling our toll free number of 1-877-385-8998; you will require a valid prescription.


How to take Zofran ODT?

Take Zofran ODT exactly the way your doctor has prescribed it to you; do not take more or less of a dose than prescribed or for a longer duration. You can take your dose with a meal if your doctor hasn’t directed otherwise. Tablets should not be swallowed whole; instead, allow the tablet to dissolve on your tongue. You may swallow several times while it dissolves. You should notify your doctor if you are unsure how they would like you to take this medication.

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