Buy Zofran ODT (Ondansetron) - Brand & Generic

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Zofran ODT is an orally disintegrating tablet made up of a 5HT3 receptor antagonist called ondansetron. We carry the brand choice and the generic alternative of this medication in 4mg and 8mg!

Zofran ODT is prescribed to patients experiencing nausea and vomiting caused by surgery, cancer chemotherapy, or radiation treatment. Chemotherapy and radiation therapy are methods of killing cancer cells, however, they also kill healthy cells in the process. The affected (healthy) cells are usually located in the protective lining of the mouth and digestive tract which then causes irritation leading to symptoms of nausea and vomiting. These symptoms occur after surgery usually due to the anesthesia, but may also be caused by pain or discomfort.

Zofran ODT (ondansetron) is effective at treating nausea and vomiting in post surgery, cancer chemotherapy, or radiation treatment because it is able to block the actions of the chemicals in the body that cause you to have these reactions (nausea and vomiting).

Your doctor will tell you before prescribing you Zofran ODT (ondansetron) exactly how to take this medication. Follow his or her directions, they can usually be found on the prescription label if you forget.

Zofran ODT is taken with or without food, usually at the start of your surgery, chemotherapy or radiation treatment. It should not be swallowed whole; to properly use this medication, allow it to dissolve in your mouth while swallowing several times. Do not chew, crush, break, or swallow this tablet whole.

Ensure the lid is tightly closed when not in use. Avoid keeping this medication in an area where it risks becoming wet or hot. Keep out of reach of children.

Do not use Zofran ODT (ondansetron)

Zofran ODT should not be used by those who are allergic to ondansetron or other similar medicines (dolasetron, granisetron, palonosetron), or if you also use apomorphine (Apokyn).

This medication is not approved for those under the age of 4 years old.

Dose adjustment or special precautions may be required

To ensure this medication is safe for you, tell your doctor if you have liver disease, an electrolyte imbalance, congestive heart failure, slow heartbeats, a personal or family history of long QT syndrome, or a blockage in your digestive tract (stomach or intestines).

Tell your doctor if you have PKU-phenylketonuria.


This medication is not expected to harm an unborn baby however it is still recommended you tell your doctor if you are pregnant or plan on becoming pregnant.

It is not known if this medication will pass into breast milk or if it will harm a nursing infant. Tell your doctor if you are breast feeding.

Common side effects of Zofran ODT (ondansetron) may include:

  • diarrhea or constipation;
  • headache;
  • drowsiness; or
  • tired feeling.

The above side effects should not alarm you.

Serious side effects of Zofran ODT (ondansetron) may include:

  • severe constipation, stomach pain, or bloating;
  • headache with chest pain and severe dizziness, fainting, fast or pounding heartbeats;
  • fast or pounding heartbeats;
  • jaundice (yellowing of the skin or eyes);
  • blurred vision or temporary vision loss (lasting from only a few minutes to several hours); or

high levels of serotonin in the body: agitation, hallucinations, fever, fast heart rate, overactive reflexes, nausea, vomiting, diarrhea, loss of coordination, fainting.

If you have any of the above side effects or signs, contact your doctor right away.

Please note this is not a complete list of side effects. Not everyone experiences side effects; they are not guaranteed. If you do have side effects and they become unmanageable, consult your doctor about alternate medications.

What will my dosage be based on?

Your dose will based on your medical condition and response to therapy. Doses for children may also be based on age and weight.

What is the max dose for a person who has liver problems?

If you have liver problems, do not exceed more than 8mg in 24 hours (1 day).

Is this medication used for anything else?

Sometimes, this medication may be used to treat excessive vomiting in pregnancy and vomiting in children due to acute gastroenteritis (inflammation and/or irritation of the digestive tract).

What are medications that may interact with Zofran?

Medications that may interact with Zofran include narcotic medications or medications used to treat depression, nausea and vomiting, or a psychiatric disorder.

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