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Xigduo XR is an oral extended release tablet consisting of two antidiabetic drugs called dapagliflozin and metformin. We carry the brand choice of this medication in 5mg/1000mg, 10mg/500mg, and 10mg/1000mg!

Xigduo XR is prescribed to control blood sugar levels in those with diabetes type 2, often times aided with diet and exercise. Normally, when we eat food and our blood sugar rises, our pancreas will produce insulin, which turns the sugar into energy for our body to use later. In people with diabetes type 2, they either cannot make enough insulin or their body does not know how to use it properly. If this condition goes untreated for too long, complications such as kidney damage, dialysis, eye damage leading to permanent vision loss, or an increased risk for heart disease or stroke can occur.

Xigduo XR (dapagliflozin and metformin) is effective at controlling blood sugar levels because dapagliflozin is able to remove sugar from the blood stream while metformin reduces the sugar production in the liver while also reducing sugar absorption in the intestines.

Important information

Follow only the directions given to you by your doctor. Do not take more or less of a dose than directed. For the full benefit of the medication, ensure you take it regularly and create a routine by taking it around the same time every day.

You may need kidney function tests before you start taking this medication.

Your doctor may prescribe you a glucagon injection kit in case you have a severe case of hypoglycemia. Ensure all household members and close friends and family members, including yourself, understand how to properly use it.

Sometimes, vitamin B12 is prescribed along with this medication; take only the amount of vitamin b12 that has been prescribed to you.

Store this medication at room temperature away from heat, moisture, and children.

How this medication is taken

This medication should be taken with food to help prevent an upset stomach from occurring. The tablet must be swallowed whole and should never be chewed, crushed, or broken open.


Do not use Xigduo XR (dapagliflozin and metformin)

This medication should not be used by anyone who is allergic to dapagliflozin (Farxiga) or metformin, or if you have severe kidney disease, are on dialysis, or metabolic acidosis or diabetic ketoacidosis.

Do not use Xigduo XR if you are under the age 18 years old.

Dose adjustment or special precautions may be required

To ensure this medication is safe for you, tell your doctor if you have ever had liver or kidney disease, low blood pressure, a bladder infection or urination problems, bladder cancer, heart problems, problems with your pancreas including surgery, or if you are on a low salt diet.


When you take Xigduo XR, you increase your risk of lactic acidosis, a dangerous build up of lactic acid in the bloodstream.

If you become pregnant during treatment, tell your doctor right away. Using this medication while pregnant may harm the unborn baby during the second or third trimester.

This medication may stimulate ovulation in woman who have no yet experienced menopause and may increase the risk of pregnancy. To avoid pregnancy, use effective birth control; consult your doctor to learn more about protected sex.

You should not breastfeed while being treated with Xigduo XR; if this concerns you, speak to your doctor.

Very rarely, this medication has caused serious infection in the penis and vagina. Watch for signs (see side effects) and contact your doctor right away if you feel you may have a new infection.

Side Effects

Common side effects of Xigduo XR (dapagliflozin and metformin) may include:

genital infections; headache; nausea, vomiting, diarrhea; or runny or stuffy nose, sore throat.

The above side effects should not alarm you.

Serious side effects of Xigduo XR (dapagliflozin and metformin) may include:

little or no urination.

If you have any of the above side effects, contact your doctor right away.

Please note this is not a complete list of side effects. Not everyone experiences side effects; they are not guaranteed. If you do have side effects and they become unmanageable, consult your doctor about alternate medications.

Contact your doctor if you notice signs of…

dehydration: feeling very thirsty or hot, being unable to urinate, heavy sweating, or hot and dry skin;

ketoacidosis (too much acid in the blood): nausea, vomiting, stomach pain, confusion, unusual drowsiness, or trouble breathing; or

lactic acidosis: unusual muscle pain, trouble breathing, stomach pain, vomiting, irregular heart rate, dizziness, feeling cold, or feeling very weak or tired.


What other drugs may interact with this medication?

Other drugs that may interact with this medication include digoxin (digitalis, Lanoxin), a diuretic or "water pill", insulin or other oral diabetes medications, rifampin, and ritonavir. This is not a complete list of drugs that interact with Xigduo XR.

Can children use Xigduo XR?

No. This medication should not be used by anyone under the age of 18 years old. Consult your doctor about a diabetes medication suitable for children use.

What is the maximum dose for an adult with diabetes type 2?

The maximum dose for an adult with diabetes is 10mg/2000mg per day.

Can I drink alcohol while using this medication?

You should not consume alcohol while being treated with Xigduo XR as it may increase your risk of lactic acidosis as well as lower your blood sugar.

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