Vagifem side effects include:
Nausea, stomach cramps, vomiting, bloating, diarrhea, breast swelling or tenderness, nipple discharge, vaginal itching or discharge, swelling of your ankles or feet, headache (including migraines), weight changes, dizziness, cold symptoms (stuffy nose, sneezing, sore throat), acne, skin color changes, increased facial hair, thinning scalp hair, depression, changes in your menstrual periods, or break-through bleeding.
Some serious Vagifem side effects include:
Mental/mood changes (such as depression, memory loss), breast lumps, unusual vaginal bleeding (such as spotting, breakthrough bleeding, prolonged or recurrent bleeding), increased or new vaginal irritation/itching/odor/discharge, severe stomach or abdominal pain, persistent nausea or vomiting, yellowing eyes or skin, dark urine, swelling hands/ankles/feet, or increased thirst or urination.
If any side effects of Estradiol become unmanageable speak with your doctor or pharmacist for help in managing any side effects. For any serious side effects that occur speak with your doctor right away for further treatment options.