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Trizivir is an oral tablet made up of a combination of nucleoside reverse transcriptase inhibitors-NRTIs. Abacavir, lamivudine and zidovudine are the NRTIs that make up Trizivir. We carry the brand name Trizivir in 300mg/150mg/300mg. 

Trizivir (abacavir, lamivudine and zidovudine) is used to treat the human immunodeficiency virus-HIV. HIV is viral infection that slowly weakens your immune system, the body’s natural defense system again disease and infection, over time. HIV is contracted through bodily fluids such as blood, semen, vaginal fluids, and saliva, which is why an HIV infected person should never share personal items such as toothbrushes and razors and should always wear protection (like a condom) during sexual intercourse. If HIV goes untreated for too long, the HIV infected person risks developing AIDS. A person has AIDS when HIV has weakened the immune system so much to the point where it can no longer defend against disease and infection, which can become fatal. There is no cure for HIV at this time, but using medication, HIV can be kept under control and AIDS can be prevented.

Trizivir (abacavir, lamivudine and zidovudine) is effective at treating HIV because it is able to stop the growth of the virus in the body. By stopping the growth, you are giving the immune system a better fighting chance.

Use Trizivir exactly the way it has been prescribed to you by your doctor. Do not change your dosage strength or schedule without consulting your doctor first. All HIV patients should remain under the care of a doctor. Frequent medical tests will need to be done during the duration of treatment.

You may take the Trizivir tablets with or without food. Store at room temperature in a low risk area of heat and moisture.


Do not use Trizivir (abacavir, lamivudine and zidovudine)

Do not use Trizivir if you are allergic to its active ingredients (abacavir, lamivudine and zidovudine) or any type of medication that contains abacavir, lamivudine, or zidovudine, including: Combivir, Epivir, Epzicom, Retrovir, or Ziagen.

Do not use in patients who weigh less than 90 pounds.

Dose adjustment or special precautions may be required

Tell your doctor, before starting treatment, if you have ever had bone marrow suppression, kidney disease, liver disease, heart disease or high blood pressure, or a risk factor for heart disease such as smoking, diabetes, or interferon alfa.


You have a risk of developing lactic acidosis while using this medication. This is a dangerous build up of lactic acid in the blood. Ask your doctor about your risk before starting treatment.

Using Trizivir can cause life-threatening effects on the liver. This is more likely to occur in those with hepatitis C or B.

Those with hepatitis B; your infection to reactive or worsen when starting or stopping this medication.

Tell your doctor if you are pregnant or breast feeding. You will need to discuss the risks and benefits before starting treatment.

Do not allow your Trizivir supply to run out before getting your next supply. It is important you do not miss any doses, or too many doses. Taking this medication after not using it for a while can cause a dangerous or even fatal allergic reaction.

Side Effects

Common side effects of Trizivir (abacavir, lamivudine and zidovudine) may include:

headache; weakness or tiredness; nausea, vomiting; or changes in the shape or location of body fat (especially in your arms, legs, face, neck, breasts, and waist).

The above side effects should not alarm you.

Serious side effects of Trizivir (abacavir, lamivudine and zidovudine) may include:

trouble speaking or swallowing, problems with balance or eye movement, weakness or prickly feeling; swelling in your neck or throat (enlarged thyroid), menstrual changes, impotence;

lactic acidosis: unusual muscle pain, trouble breathing, stomach pain, vomiting, irregular heart rate, dizziness, feeling cold, or feeling very weak or tired;

new infection: fever, night sweats, swollen glands, cold sores, cough, wheezing, diarrhea, weight loss;

low white blood cell counts: fever, mouth sores, skin sores, sore throat, cough, trouble breathing;

low red blood cells (anemia): pale skin, unusual tiredness, feeling light-headed or short of breath, cold hands and feet;

liver problems: swelling around your midsection, right-sided upper stomach pain, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or

allergic reaction: fever; rash; nausea, vomiting, diarrhea, stomach pain; general ill feeling, extreme tiredness, body aches; shortness of breath, cough, sore throat.

If you have any of the above side effects or signs of complications, contact your doctor right away.

Please note this is not a complete list of side effects. Not everyone experiences side effects; they are not guaranteed. If you do have side effects and they become unmanageable, consult your doctor about alternate medications.


What is the average dose for an adult with HIV infection?

The average dose for an adult with HIV infection is one tablet (300mg/150mg/300mg) taken twice per day.

Can I drink alcohol while using Trizivir?

No. Do not drink alcohol while being treated with Trizivir.

Will this medication help prevent the transmission of HIV infection?

No. This medication is neither a cure for HIV nor a prevention method of HIV. This medication is used only to control the infection.

How can I tell allergic reaction symptoms apart from other side effects and complications?

You are likely having an allergic reaction if you experience symptoms from at least 2 or more of the following:                        

  • Fever   
  • Rash
  • Nausea, vomiting, diarrhea, stomach pain
  • Generally feeling ill, extreme tiredness, body aches
  • Shortness of breath, cough, sore throat.
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