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What is Trilafon?

Trilafon is an oral tablet made up of a phenothiazine called perphenazine. We carry the generic alternative of Trilafon, which is just called perphenazine, available for purchase in 2mg, 4mg, 6mg, 8mg, and 16mg.

Trilafon is prescribed to treat psychotic disorders. Psychotic disorders affect the chemicals in the brain and include common disorders such as schizophrenia and schizoaffective disorder. Common and general symptoms within psychotic disorders may include difficulty concentrating, depressed mood, anxiety, suspiciousness, delusions, and hallucinations. However, depending on what kind of psychotic disorder you have, you may show different symptoms or a different mix of symptoms. For example, people with schizophrenia usually will always have mood symptoms (such as loss of interest in previously enjoyable activities or overall sadness) together with psychotic symptoms (hallucinations and anxiety), whereas schizoaffective disorders may cause mood symptoms but not necessarily at the same time as psychotic symptoms.

No matter which symptoms you find present or which symptoms come hand in hand together, using Trilafon can help ease them. Using this medication can help reduce aggressive behavior, the desire to cause harm to yourself or others, hallucinations, and nervousness. It can help you think more clearly and participate in everyday life in a way you maybe couldn’t before. Trilafon (perphenazine) is effective at treating psychotic disorders such as schizophrenia because of its ability to aid in the restoration of the imbalance of natural chemicals, such as dopamine, in the brain.

Your dose may be changed occasionally throughout the duration of treatment. Ensure you are following each of your doctors’ directions very carefully. You may need frequent blood tests while using Trilafon.

Avoid taking Trilafon for longer or shorter than recommended, or in larger or smaller doses than prescribed. Using too much of this medication can induce a serious muscle movement disorder, which may not be reversible. You risk for this is high if you are an older adult or a senior, and is increased the longer you use the medication for.

Tell the surgeon ahead of time that you are using Trilafon if you need surgery. You may need to stop using the medicine for a short time to safely have the surgery.

Do not stop using Trilafon suddenly after long-term use. You may find yourself with unpleasant withdrawal symptoms. Ask your doctor what the best way to avoid withdrawal symptoms is when you stop using this medicine.

Store at room temperature away from moisture, heat, and light.


Trilafon should not be used by anyone who is allergic to phenothiazines (a drug class) such as (Trilafon, chlorpromazine, prochlorperazine, promethazine, thioridazine, Compazine, Phenergan, Mellaril, Thorazine, others), or if you have liver disease, brain damage, bone marrow depression, a blood cell disorder, or if you are using large amounts of alcohol or medicines that make you tired.

This medication is not approved to treat psychotic conditions associated with dementia. Using this medication for that purpose increases the patient’s risk of death significantly.

Dose adjustment or special precautions may be required.

To ensure this medication is safe for you, tell your doctor if you have severe or untreated depression, heart disease or high blood pressure, kidney disease, severe asthma, emphysema, or other breathing problems, a history of seizures, Parkinson’s disease, past or present breast cancer, adrenal gland tumor, enlarged prostate or urination problems, low levels of calcium in your blood, glaucoma, or if you have ever had a serious side effect while using a phenothiazine.

Tell your doctor if you will be in extreme temperatures or exposed to insecticide poisons during treatment.


Tell your doctor if you are pregnant or plan on becoming pregnant. There are benefits and risks you will need to discuss. Using this medication in the final 3 months of pregnancy can cause withdrawal symptoms, breathing problems, feeding problems, fussiness, tremors, and limp or stiff muscles in the newborn. However, you also have risks (withdrawal symptoms) if you suddenly stop taking your medication. Do not stop taking this medication without your doctor’s advice.

Do not breastfeed while using Trilafon; it may harm your nursing infant when it passes through breast milk.

Side Effects

Common side effects of Trilafon (perphenazine) may include:

mild dizziness or drowsiness; blurred vision, headache; sleep problems (insomnia), strange dreams; loss of appetite, vomiting, diarrhea, constipation; increased sweating or urination; dry mouth or stuffy nose; breast swelling or discharge; or mild itching or skin rash.

The above side effects should not alarm you.

Serious side effects of Trilafon (perphenazine) may include:

feeling restless, jittery, or agitated; confusion, unusual thoughts or behavior; seizure (convulsions); extreme drowsiness or dizziness, feeling like you might pass out; severe bloating or stomach cramps; little or no urinating; slow heart rate, weak pulse, weak or shallow breathing; sudden weakness or ill feeling, fever, chills, sore throat, mouth sores, red or swollen gums, trouble swallowing;

severe nervous system reaction; very stiff (rigid) muscles, high fever, sweating, fast or uneven heartbeats.; or

serious movement disorder; tremors or shaking in your arms or legs, uncontrolled muscle movements in your face (chewing, lip smacking, frowning, tongue movement, blinking or eye movement), or any new or unusual muscle movements you cannot control.

If you have any of the above side effects or signs of complications, contact your doctor right away.


What is Perphenazine?

Trilafon is a medication that is used to treat specific mental and mood disorders. Such examples are schizophrenia, manic phase of bipolar disorder, and schizoaffective disorder. When you begin to take this medication you may notice that you are able to think more clearly, feel less nervous, and can take part in everyday life. It can also reduce any negative aggressive behavior and the desire to not only hurt others, but yourself as well. It will as well decrease your experiences with hallucinations. This medication generally works by restoring the balance of a natural substance in the brain called dopamine. Trilafon comes in four different strengths which are 2mg, 4mg, 8mg, and 16mg. If you have any questions regarding this medication or any inquiries in general, feel free to give us a call at our toll free number 1-877-385-8998.     

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