Buy Trexall (Methotrexate) - Brand & Generic

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What is Trexall used for?

Trexall is an oral tablet consisting of an antimetabolite called methotrexate. We carry the generic alternative of Trexall, called methotrexate, in 10mg!

Trexall is a breast, skin, and head and neck cancer treatment. All these types of cancers are similar in the way that they begin. Breast cancer occurs when healthy breast cells start to mutate and change. This may be caused partially from genes (passed on from your parents) and partially from environmental factors (such as what you eat and if you exercise). Skin cancer also occurs due to the actions of cells; it occurs when the cells that make up your skin begin to reproduce abnormally, which can eventually spread to other areas of the body. Skin cancer is caused primarily by environmental factors and beyond-control factors such as spending excessive time in the sun or tanning beds, whether you live in a warm or high elevation location (environmental causes) or due to having light skin, eyes, and/or hair, or aging (beyond-control factors).  Head and neck cancer is very much like skin cancer; it begins when cells located in the head and neck begin to grow out of control and over-crowd normal cells. This makes it harder for the body to function and allows the cells/cancer to spread. Similar to skin cancer, the causes of this type of cancer are mixed between things you can control and things you cannot. This includes factors such as tobacco and alcohol use and poor nutrition (environmental factors) as well as gender, age, and certain illness (beyond-control factors).

Trexall (methotrexate) is effective at treating certain types of cancer because methotrexate is able to interfere with the growth of certain cells inside the body. Methotrexate’s affect is extra effective when it comes to fast-reproducing cells, such as cancer cells, bone marrow cells, and skin cells.

Additionally, Trexall can be used for the treatment of psoriasis and certain forms of rheumatoid. These two conditions are also caused by certain actions of certain cells.

Use this medication exactly the way it has been prescribed to you. Prescription labels usually have the directions written on them. You will need your blood tested often while being treated with this medication.

This tablet is taken once or twice per week, not daily, in some cases. You must ensure you are taking the correct dose at the correct time. There have been fatal situations leading to death caused by using this drug every day when it was only needed once or twice a week.

Store tablets at room temperature in a low risk area of heat and moisture.

Do not use Trexall (methotrexate)

Do not use this medication if you are allergic to methotrexate.

Do not use this medication for the treatment of psoriasis or rheumatoid arthritis if you also have alcoholism, cirrhosis, or chronic liver disease, low blood cell counts, a weak immune system or bone marrow disorder, or if you are pregnant or breast-feeding.

Dose adjustment or special precautions may be required

To ensure this medication is safe for you, tell your doctor if you have kidney or lung disease, any type of infection, or radiation treatments.


Whether it’s the father or the mother, using this medication can cause harm to an unborn child or birth defects once the unborn child is born.

You may find this medication affects fertility.  

Common side effects of Trexall (methotrexate) may include:

  • fever, chills, tiredness, not feeling well;
  • mouth sores;
  • nausea, upset stomach;
  • dizziness; or
  • abnormal liver function tests.

The above side effects should not alarm you.

Serious side effects of Trexall (methotrexate) may include:

  • fever, chills, swollen lymph glands, night sweats, weight loss;
  • vomiting, white patches or sores inside your mouth or on your lips;
  • diarrhea, blood in your urine or stools;
  • dry cough, cough with mucus, stabbing chest pain, wheezing, feeling short of breath;
  • seizure (convulsions);

kidney problems - little or no urination, swelling in your feet or ankles;

liver problems - stomach pain (upper right side), dark urine, jaundice (yellowing of the skin or eyes);

nerve problems - confusion, weakness, drowsiness, coordination problems, feeling irritable, headache, neck stiffness, vision problems, loss of movement in any part of your body; or

signs of tumor cell breakdown - confusion, tiredness, numbness or tingling, muscle cramps, muscle weakness, vomiting, diarrhea, fast or slow heart rate, seizure.

If you have any of the above side effects or signs of complications, contact your doctor right away.

Please note this is not a complete list of side effects. Not everyone experiences side effects; they are not guaranteed. If you do have side effects and they become unmanageable, consult your doctor about alternate medications.

What should I avoid while using this medication?

Avoid drinking alcohol. It may cause your risk of liver damage to increase.

How old do you have to be to use Trexall?

To use this medication, you must be at least 18 years old. Anyone younger than 18 years old should not take this medication unless specifically directed to by a doctor.

Are there any drug interactions associated with Trexall?

Yes. Other drugs that may interact with this medication includes medicines for infections, tuberculosis, depression, birth control, hormone replacement, high cholesterol, heart problems, high blood pressure, seizures, or pain or arthritis medicines (including acetaminophen, Tylenol, Advil, Motrin, and Aleve).

What else should I know about this medication?

You may develop a serious infection If you have any live vaccine shots while using this medication. This includes vaccines for measles, mumps, rubella, polio, shingles, and more.

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