What is Trelegy Ellipta used for?

Trelegy Ellipta is prescribed for long-term maintenance treatment of Bronchospasm, which is associated with chronic obstructive pulmonary disease (COPD). Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory lung disease that impairs the airflow out of your lungs. Symptoms include breathing difficulty, cough, mucus (sputum) production and wheezing.

Bronchitis and Emphysema are the two most common conditions that contribute to COPD.

When you have Bronchitis, your bronchial tubes become inflamed and narrowed and your lungs produce more mucus, which can further block the narrowed tubes. You develop a chronic cough trying to clear your airways.

Emphysema occurs when the walls between the air sacs in your lungs become damaged and lose their elasticity. As the walls of the air sacs also sustain damage, instead of many tiny air sacs, there are fewer but larger ones that reduce the amount of gas exchange.

Because Trelegy Ellipta is a long-term maintenance medication, it can end up being costly. You can buy Trelegy Ellipta (Fluticasone/Umeclidinium/Vilanterol) online at My Drug Center at an affordable price. With proper management, most people with COPD can achieve symptom control and quality of life, as well as reduced risk of other associated conditions.

How does Trelegy Ellipta work?

Trelegy Ellipta is an inhalation powder containing a combination of 3 active ingredients: fluticasone, umeclidinium, and vilanterol. The Fluticasone dosage is a steroid that decreases the swelling and inflammation within the airways when it is inhaled. Umeclidinium is an anticholinergic and Vilanterol is a bronchodilator. The doses of these ingredients work by relaxing muscles in the airways to improve breathing. [1]

Before taking your prescribed Trelegy Ellipta dosage, read all the instructions that was provided by your pharmacist. This is important so that you understand how to use the inhaler and blister pack to administer the right dose of medication. Take one Trelegy Ellipta dosage, once a day.

This medication is not meant for quick relief from asthma attacks. You should also have a rescue inhaler on hand. Allow at least a minute between use of multiple inhalers and rinse your mouth with water to prevent infections. Never swallow the rinse-water.

Make sure you take Trelegy Ellipta at the same time each day to create a routine for yourself and to ensure an even spread of the Fluticasone/Umeclidinium/Vilanterol dosage in your system. For optimal results take this medication on a regular basis. Do not change or increase your dose. You should continue taking this medication even if you feel well.

This medication may contain medical and non medical ingredients that could cause an allergic reaction. Consult with your doctor about any known allergies before taking Trelegy Ellipta. Speak with your doctor about any known medical conditions relating to high blood pressure, bone loss, depression, diabetes, eye problems, heart problems, recent infections, liver problems, overactive thyroid, and seizures. Tell your doctor about any current medications or supplementation to avoid interactions with Trelegy Ellipta.

Keep track which inhalers are used more often in case there is a worsening of COPD symptoms. Speak with your doctor if you find that you need your rescue inhaler more often.

You may experience irregular heart rhythm (QT prolongation) while taking this medication. Risk of QT prolongation is increased with salt deficiencies and use of diuretics can also increase this risk.

Long term use of croticosteroids can cause your body to have challenges responding to physical stress. You should tell your doctor or dentist that you are using this medication before any surgery, operations, or any procedures. If this medication is required for long term use have an ID bracelet or documentation. This can help identify the use of this medication in cases where you might be unable to speak or explain your condition. 

While taking Trelegy Ellipta your body may become more prone to infections. Washing your hands and practising good hygiene can help prevent the spread of infections or other diseases. Avoid coming into contact with transmittable infections like the flu, measles or chickenpox. 

Common Trelegy Ellipta side effects include:

Headache, back pain, changes in taste, diarrhea, cough, mouth pain, sore throat, and gastroenteritis (nausea, vomiting, cramps, and fever)

If any side effects of side effects of Fluticasone/Umeclidinium/Vilanterol become unmanageable speak with your doctor or pharmacist for help in managing any side effects. For any serious side effects that occur speak with your doctor right away for further treatment options.

How to use Trelegy Ellipta?

It is important to use this medication exactly the way your doctor has directed you to; this includes how often you use the inhaler. Trelegy is a powder that comes with a special inhaler, called an Ellipta inhaler. The Ellipta inhaler is preloaded with blister packs that contain the fixed amount of Trelegy powder.

Each time the device cover is opened, a blister of Trelegy will be loaded into the inhaler. If you open and then close the inhaler cover without inhaling, you will lose the dose; do not open the cover until you are ready to take your dose.

When you are ready to take your dose, slide the cover on the inhaler down until you hear a click; breathe out gently before placing the mouthpiece in your mouth; deeply breathe in and hold for 5 seconds.

To avoid an oral yeast infection, rinse your mouth thoroughly with water after each use.  Trelegy Ellipta is typically only needed once per day, and for best results, it should be used at the same time each day. If you are still unsure how to use this medication, it is recommended to consult with your doctor and ask any questions you may have before starting treatment.

How much does Trelegy Ellipta cost?

The cost of medication will vary depending on where you purchase your supply from. Each pharmacy will typically vary in price, which is especially true when comparing local United States pharmacies to international pharmacies such as MyDrugCenter.

Many medications – including Trelegy Ellipta – can be found much cheaper internationally as oppose to pharmacies in the United States. For example, the price for a single inhaler at MyDrugCenter is $115.00, about 6 times cheaper than the average retail cost for a single inhaler in the United States.

MyDrugCenter allows you to purchase your medication without having to leave the comfort of your own home while also having it shipped directly to your front door, so not only is it easier on your wallet, but also makes filling your prescription an easier process altogether. Order today by calling our toll-free number 1-877-385-8998; keep in mind, a valid prescription is required to purchase this medication.

What is Trelegy Ellipta used for?

Trelegy Ellipta is an inhaled medication used for the treatment of symptoms caused by chronic obstructive pulmonary disease (COPD). COPD is a long-term lung disease where the airflow from your lungs is limited, usually a result of long-term irritation and inflammation in your lungs.

When the airways of the lungs become inflamed, they become narrow, often tend to collapse when you breathe out, and may cause the airways to become clogged with mucus. This results in a limited amount of airflow through the bronchial tubes making it hard to inhale and exhale air out of your lungs.

This results in symptoms such as shortness of breath, wheezing and chest tightness, and a dry cough. Bronchitis, which is a condition characterized by inflammation in the lining of your bronchial tubes (which carries oxygen to and from your lungs), can be considered a type of COPD. Emphysema is another condition which can be considered COPD; it occurs when the air sacs in the lung become damaged and stretched.

These additional conditions are considered COPD because they obstruct airflow to and from the lungs; both of these conditions can also be treated with Trelegy Ellipta. Using this medication can help improve the symptoms and prevent bronchospasms, which are a sudden constriction of the muscles in the bronchiole walls resulting in mild to severe breathing difficulties.

How does Trelegy Ellipta work?

The reason Trelegy Ellipta is effective in treating COPD symptoms is due to the active ingredients. Active ingredients are what make medications therapeutically effective; Trelegy Ellipta has 3 active ingredients which all work towards your symptoms in different ways. Every drug is divided into classes based on their mechanism of action; Trelegy Ellipta contains drugs classified as corticosteroids, anticholinergics, and long-acting beta-agonists (LABAs). Additionally, anticholinergics and LABAs can be considered bronchodilators.

Corticosteroids are drugs which resemble cortisol, a naturally produced hormone secreted by the adrenal glands. Drugs of this class are effective in lowering inflammation. They help prevent the release of certain substances that cause inflammation – such as prostaglandins and leukotriene. They do this by binding to the glucocorticoid receptor, allowing the activation of lipocortin which inhibits an enzyme associated with the inflammation-causing substances. Fluticasone is the corticosteroid found in Trelegy Ellipta.

Anticholinergics are drugs which prevent the actions of acetylcholine, a neurotransmitter (chemical messenger) that controls certain body functions by sending signals between certain cells.  Anticholinergics block the muscarinic receptors in the smooth muscle of the airway which helps to prevent acetylcholine from sending signals that result in bronchoconstriction. This allows for more relaxed airway muscles and easier air flow. Umeclidinium is the anticholinergic in Trelegy Ellipta.

Finally, long-acting beta-agonists (LABAs) are drugs that are inhaled to help open the airways by relaxing smooth muscle in the air ways. They work by stimulating certain enzymes which helps to convert a certain energy-carrying molecule into a second messenger molecule called cyclic AMP. Increases in cyclic AMP are associated with bronchial (airway) smooth muscle relaxation while also preventing the release of certain hypersensitivity mediators. Vilanterol is the LABA in Trelegy Ellipta; it is a unique LABA as it is typically only used in combination medications.

How long does Trelegy stay in your system?

The amount of time it takes the medication to clear from your system will vary slightly between each patient. You can find an estimate as to how long it may take by using the half-life of the medication. All medications have a half-life, which measures the amount of time it takes the concentration of the medication to drop by half (50%). If you take the half-life of the medication and multiply it by 5, you will get the estimated time it will take to clear from the system. For example, Trelegy Ellipta has an average half-life of about 15 hours, therefore following your last dose; it could take around 75 hours (a little more than 3 days) to completely clear from your system.

How effective is Trelegy Ellipta compared to other inhalers?

In one of the largest studies conducted on patients with COPD, researchers found that once-daily use of Trelegy Ellipta was significantly more effective than other inhalers, including inhalers that used umeclidinium bromide/vilanterol. [2] This study was conducted in 2018 and took place over a span of 52 weeks.