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Tofranil is an oral medication consisting of a tricyclic antidepressant called imipramine hydrochloride. We carry the brand choice and the generic alternative of this medication in 10mg and 25mg. 

Tofranil is used to treat symptoms that occur within a condition called depression. Depression is when a person has constant feelings of doubt, hopelessness, and overwhelming sadness. It is normal to have days where you feel down, but when it occurs all the time, most –if not- every day, then you may have depression. Doctors aren’t sure exactly why depression happens, they know there are factors that will lead to depression, but the exact science of it is unknown. What doctors believe depression is a result of is imbalanced chemicals and neurotransmitters in the brain (such as norepinephrine). Some symptoms of depression that are improvable with Tofranil include mood, sleep, appetite, and energy levels, which may also help restore your interest in other activities and daily life.

Tofranil (imipramine hydrochloride) is effective at treating depression symptoms because it is able to restore the proper balance of chemicals and neurotransmitters in the brain.

Additionally, this medication may also be used in children to help with nighttime bed wetting. Since Tofranil is able to affect certain chemicals, it can also interfere with substances in the bladder, which will help reduce the number of bed-wetting accidents.

Tofranil should be taken only the way your doctor has prescribed it to you. Do not take more or less of a dose or for longer than recommended. Do not suddenly stop taking this medication without first consulting your doctor.

Take this medication 1-4 times a day – you may take the dose with or without food. If this medication makes you drowsy, you may need to take the entire dose all at once, at bedtime.

For bed-wetting - this medication should be taken 1 hour before bedtime.


Do not use Tofranil (imipramine hydrochloride)

Do not use this medication if you have recently had a heart attack or used an MAO inhibitor, or if you are allergic to imipramine or other similar antidepressants.

Do not give this medication to a child without the medical advice of a doctor.

Dose adjustment or special precautions may be required.

To ensure this medication is safe for you, tell your doctor if you have heart disease, a history of heart attack, stroke, seizures, bipolar disorder, schizophrenia or other mental illness, kidney or liver disease, overactive thyroid, adrenal gland tumor, diabetes, narrow-angle glaucoma, problems with urination, or a condition in which you are being treated with electroconvulsive therapy.


Some younger patients have thoughts about suicide when first taking Tofranil. Stay alert to any possible mood or behavior changes. Tell your doctor about any new or worsening symptoms.

It has not yet been established if this medication will harm an unborn child. You should speak with your doctor before using this product.

It is not known if this medication will pass into breast milk or if it will harm a nursing infant. Tell your doctor if you are breastfeeding.

Older patients may be more sensitive to the side effects of this drug.

Side Effects

Common side effects of Tofranil (imipramine hydrochloride) may include:

tingly feeling, weakness, lack of coordination; dry mouth, nausea, vomiting, constipation, diarrhea; vision changes, ringing in your ears; breast swelling (in men or women); or decreased sex drive, impotence, or difficulty having an orgasm.

The above side effects should not alarm you.

Serious side effects of Tofranil (imipramine hydrochloride) may include:

blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights; a light-headed feeling, like you might pass out; new or worsening chest pain, pounding heartbeats or fluttering in your chest; sudden numbness or weakness, problems with vision, speech, or balance; fever, sore throat; confusion, hallucinations, unusual thoughts or behavior; painful or difficult urination; seizure (convulsions); or jaundice (yellowing of the skin or eyes).

If you have any of the above side effects or signs of complications, contact your doctor right away.

Please note this is not a complete list of side effects. Not everyone experiences side effects; they are not guaranteed. If you do have side effects and they become unmanageable, consult your doctor about alternate medications.


What is Tofranil?

Tofranil is a medication that is used to treat depression. Although, at times, it is used alongside various therapies to treat nighttime bed-wetting, which is normally called enuresis, in children. In using this medication to treat your depression you might find that it may improve your mood, sleep, appetite, and overall energy levels and can help restore your interest in everyday life. When you begin taking your dose this medication works by restoring the balance of a natural substance within the brain called a neurotransmitter. Tofranil comes in two different strengths which are 10mg and 25mg. If you have any questions regarding this medication or any inquiries in general, feel free to give us a call at our toll free number 1-877-385-8998.     


How much does Tofranil cost?

Tofranil falls in line with Tier 2 of Medicare’s formulary. Generally, anything on Tier 2 is referred to as a “non-preferred generic”. While these medications may be expensive you can find a more affordable option on an online Canadian pharmacy such as My Drug Center. We have a starting price of $42.00 for 100 pills.

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