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What is Surmontil (Trimipramine) prescribed for?

While most people may feel sad or depressed at times. It is normal reaction to life’s struggles. But then there is intense sadness, which includes helpless, hopeless, and worthless feelings. And they may last for days to weeks and it keeps you from living your life. And while it may seem hopeless, there is a variety of medical treatments for clinical depression.

This medication is used in the treatment towards depression. By taking this medication it may improve your mood and your overall sense of well being, and will allow you to partake in the enjoyments of everyday life. Trimipramine is a tricyclic antidepressant. It works by restoring the balance of a certain natural substance in the brain known as neurotransmitters.

Read any information given to you by your doctor, and if you have any questions or concerns regarding this medication, please consult with your doctor or pharmacist.

This medication is taken by mouth with or without food, usually 1 to 3 times a day or as directed to you by your doctor. If you are told to only take this medication once a day, it is best to take it at bedtime to decrease the risk of drowsiness.  Remember the dosage is based on your medical condition, response to therapy and overall treatment. Your doctor may also start you on a low dose and then gradually increase it as time goes by.

This medication does not work right away. It may take 2 to 4 weeks before you experience the full benefits. However, use this medication regularly in order to get the most benefit from it in the future.


Before taking this medication, it is best to advise your doctor if you are allergic to Trimipramine; or to other tricyclic antidepressants (e.g., amitriptyline, imipramine); or to any other medications or allergies in general. This product may contain inactive ingredients, which can cause allergic reactions or other problems.

You should also let your doctor know of all of your medical history. Especially if you have ever dealt with any of these experiences in the past;  blood problems (e.g., agranulocytosis, thrombocytopenia), breathing problems (e.g., asthma, chronic obstructive pulmonary disorder-COPD), diabetes, electroshock therapy, personal or family history of glaucoma (angle-closure type), heart problems (e.g., recent heart attack, arrhythmias, coronary artery disease), intestinal problems (e.g., chronic constipation, ileus), kidney problems, liver problems, other mental/mood conditions (e.g., bipolar disorder, psychosis), family history of mental/mood conditions (e.g., suicide, bipolar disorder), seizures, conditions that may increase your risk of seizures (e.g., bulimia, organic brain disease, alcohol withdrawal), overactive thyroid (hyperthyroidism), problems urinating (urinary retention, enlarged prostate).

Trimipramine may cause a condition that affects the heart rhythm (QT prolongation). QT prolongation can rarely cause serious (rarely fatal) fast/irregular heartbeat and other symptoms (such as severe dizziness, fainting) that need medical attention right away.

The risk of QT prolongation may be increased if you have certain medical conditions or are taking other drugs that may cause QT prolongation. Before using trimipramine, tell your doctor or pharmacist of all the drugs you take and if you have any of the following conditions: certain heart problems (heart failure, slow heartbeat, QT prolongation in the EKG), family history of certain heart problems (QT prolongation in the EKG, sudden cardiac death).

Low levels of potassium or magnesium in the blood may also increase your risk of QT prolongation. This risk may increase if you use certain drugs (such as diuretics/"water pills") or if you have conditions such as severe sweating, diarrhea, or vomiting. Talk to your doctor about using trimipramine safely.

Side Effects

While minor, some of these side effects may occur. They are as follows; Dizziness, drowsiness, difficulty urinating, headache, weakness, changes in appetite/weight, dry mouth, blurred vision, and constipation may occur. However if any of these persist or worsen, it’s best to speak with your doctor right away.

To prevent constipation, eat dietary fiber, drink enough water, and exercise. You may also need to take a laxative. Ask your pharmacist which type of laxative is right for you.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.


What happens if I suddenly stop taking this medication?

There may be a relapse in symptoms as well as side effects. You should speak your doctor before stop taking this medication.


 What is the best dosage to take?

The diagnosis with your doctor will be able to determine the best dosage for your treatment. Work with your doctor closely for dosage and dosing schedules.


 What happens if I miss a dose?

You should take the missed dose as soon you realize you have forgotten. If the forgotten dose is closer to your next scheduled dose, take the next schedule dose to avoid overlapping in dose.


 What is the best way to store this medication?

This medication is stored at room temperature, and should be kept away from children and pets. Do not throw away this medication in the wastebasket. If you are uncertain how to dispose of this medication speak with your pharmacist for help in safely disposing of this medication.

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