Rapamune (Sirolimus)

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What is Rapamune (Sirolimus) prescribed for?

When your kidneys don’t work as they should, waste and extra fluids build up in the body. You may choose to remedy this problem with a kidney transplant. Rapamune is one medication that is used with others to prevent the rejection of a kidney transplant. It is known as an immunosuppressants drug. It goes to work by weakening your body’s immune system ti help your body accept the new organ as if it were your own.

Also on the rare occurrence, Sirolimus may also be used to treat Lymphangioleiomyomatosis, which is a rare lung disease that tends to affect woman of child bearing age. With this disease muscles cells that line the lungs’ airways and blood vessels, begin to multiply abnormally, therefore these muscle cells spread into areas of the lung where they do not belong.

If you have any questions or concerns regarding this medication, consult with your doctor or pharmacist on the matter. Take this medication directly has prescribed, and make sure to read the instructions on the prescription label.  And if you have any concerns, speak with your medical professional.

This medication is taken by mouth, once a day. Swallow the medication whole. Do not crush, chew, or split the tablets. If you have an upset stomach or nausea, you may take this medication with food.  However it is important to stick to one way of taking this medication. Either with or without food. Once you choose one, you cannot undo it.

Remember the dosage is based on your weight, medical condition, lab tests, and your overall response to the treatment. Do not increase the dose or take it more often then what has been prescribed to you. You condition will not get any better any faster, and you run the risk of side effects.

Before taking this medication, it is best to advise your doctor if you are allergic Sirolimus; or to temsirolimus; or to any other medications or allergies in general. This product may contain inactive ingredients, which can cause allergic reactions or other problems.

Before taking this medication, it is for the best to inform your doctor of your Medical history, especially if you have ever had the following; liver disease, high cholesterol/triglyceride levels, cancer, any recent/current infections.

Sirolimus can make you more likely to get infections or may worsen any current infections. Wash your hands well to prevent the spread of infection. Avoid contact with people who have infections that may spread to others (such as chickenpox, measles, flu). Consult your doctor if you have been exposed to an infection or for more details.

Do not have immunizations/vaccinations without the consent of your doctor. Avoid contact with people who have recently received live vaccines (such as flu vaccine inhaled through the nose).

This medication may increase your risk of developing skin cancer. Limit your time in the sun. Avoid tanning booths and sunlamps. Use sunscreen and wear protective clothing when outdoors.

While minor, some of these side effects may occur. They are as follows; Diarrhea, joint pain, shaking, acne, or trouble sleeping may occur. However if any of these persist or worsen, it’s best to speak with your doctor right away.

Tell your doctor right away if you have any serious side effects, including: nausea/vomiting that doesn't stop, yellowing eyes/skin, dark urine, muscle pain/cramps, bone pain, increased thirst/hunger, frequent urination, hearing problems (such as hearing loss, ringing in the ears), unusual tiredness, fast/slow/irregular heartbeat, easy bruising/bleeding, mental/mood changes, swelling ankles/feet, severe headache, dizziness, stomach/abdominal pain, missed/heavy/painful periods, signs of kidney problems (such as change in the amount of urine, frothy urine), pain/redness/swelling of arms or legs, swelling abdomen.

Get medical help right away if you have any very serious side effects, including: chest pain, shortness of breath.

This medication may increase your risk of getting a rare but very serious (possibly fatal) brain infection (progressive multifocal leukoencephalopathy-PML). Get medical help right away if you have any of these side effects: clumsiness, loss of coordination/balance, weakness, sudden change in your thinking (such as confusion, difficulty concentrating, memory loss), difficulty talking/walking, seizure, vision changes.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any of the following symptoms of a serious allergic reaction: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

What happens if I suddenly stop taking this medication?

There may be a relapse in symptoms as well as side effects. You should speak your doctor before stop taking this medication.

 

 What is the best dosage to take?

The diagnosis with your doctor will be able to determine the best dosage for your treatment. Work with your doctor closely for dosage and dosing schedules.

 

 What happens if I miss a dose?

You should take the missed dose as soon you realize you have forgotten. If the forgotten dose is closer to your next scheduled dose, take the next schedule dose to avoid overlapping in dose.

 

 What is the best way to store this medication?

This medication is stored at room temperature, and should be kept away from children and pets. Do not throw away this medication in the wastebasket. If you are uncertain how to dispose of this medication speak with your pharmacist for help in safely disposing of this medication.

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