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What is Ranexa (Ranolazine) prescribed for?

Chronic angina is a common cardiovascular condition that affects people all over the world. And it causes a significant disability with those suffering from it, in their daily activities.  Angina is usually a symptom of coronary heart disease. And the chest pain usually occurs because the heart is not getting enough oxygen from the blood. Symptoms include chest pain and tightness.  This may also include pain in the neck, jaw, shoulders, arms and back.

Alongside the medication, lifestyle changes such as an increase in exercise, and diet, may help prevent the symptoms from angina.

Normally this medication is used with other medicines to gain the most benefit. This medication manages this condition and offers relief from the uncomfortable and debilitating symptoms.

If you have any questions or concerns regarding this medication, consult with your doctor or pharmacist on the matter. Take this medication directly has prescribed, and make sure to read the instructions on the prescription label.  And if you have any concerns, speak with your medical professional.

You may take this medication with or without food.  Make sure to swallow the tablet whole. Usually twice a day unless directed otherwise by your doctor. Do not try to break, crush, or chew on the tablet. Doing so may release the drug all at once and therefore increases the risk of any side effects.

Take this medication exactly has prescribed. Do not increase your dose or take it for any longer then what has been directed to you.


Before taking this medication, it is best to advise your doctor if you are allergic Ranolazine; or to any other medications or allergies in general. This product may contain inactive ingredients, which can cause allergic reactions or other problems.

Also notify your doctor if you have cirrhosis of the liver

Before taking this medication, it is for the best to inform your doctor of your Medical history, especially if you have ever had the following; clarithromycin; nefazodone; St. John's wort; antifungal medicine - itraconazole, ketoconazole; HIV or AIDS medicine - indinavir, lopinavir/ritonavir, nelfinavir, ritonavir, saquinavir; tuberculosis medicine - rifabutin, rifampin, rifapentine; or seizure medicine-carbamazepine, phenobarbital, phenytoin. To make sure Ranexa is safe for you, tell your doctor if you have: a heart rhythm disorder; liver disease; kidney disease; ora personal or family history of long QT syndrome.

Side Effects

While minor, some of these side effects may occur. They are as follows; nausea, constipation; headache; or dizziness.However if any of these persist or worsen, it’s best to speak with your doctor right away.

If you begin to experience any of these side effects, you should contact your doctor at once. And let them know if you have any of the following; a light-headed feeling, like you might pass out; headache with chest pain and severe dizziness, fast or pounding heartbeats; or kidney problems - little or no urination; painful or difficult urination, swelling in your feet or ankles; feeling tired or short of breath.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any of the following symptoms of a serious allergic reaction: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.


What is Ranexa?


Ranexa is an oral medication available in tablet form. Each Ranexa tablet contains 375mg, 500mg, or 750mg of a drug called ranolazine; these tablets are available only with a prescription and can be purchased here at our Canadian Pharmacy.


What is Ranexa used for?


Ranexa is an anti-anginal medication used for the treatment of chronic angina in adults.


How does Ranexa work?


The exact mechanism of action for Ranexa is undetermined. However, doctors believe that Ranexa is able to reduce the amount of sodium ions flowing into the muscle cells of the heart. Reducing this flow of ions into heart cells is thought to help the heart “calm down” and relax, allowing an improvement in blood flow and a reduction in angina symptoms.


Why is Ranexa so expensive?


In the United States, Ranexa is typically listed as a tier 3 drug. Tier 3 drugs are preferred brand name drugs and have a higher cost than other tier 1 or 2 drugs. Additionally, in the United States, the generic for Ranexa was only approved in early 2019. Ranexa was a brand name medication with no generic alternative until only recently, which may factor into the expensive price. In other areas of the world, Ranexa can be found at a much cheaper cost; access these prices when you buy Ranexa online at our certified online Canadian Pharmacy, My Drug Center.


What are the side effects of Ranexa?


Common side effects of Ranexa include nausea, constipation, headache, or dizziness. Though you may experience different side effects from the ones listed here or you may not experience any at all. Each individual may react differently to this medication. Side effects are likely to become less frequent once the body adjusts to the medication.


How long does Ranexa take to work?


It may take a few days for your body to adjust to the medication before your symptoms improve. If there is no improvement after a few days, you may need a dose adjustment. The exact amount of time it takes for Ranexa to work may vary from person to person.


Who makes Ranexa?


Ranexa is manufactured by Gilead, an American biotechnology company with locations in California, Florida, and Washington.


How much does Ranexa cost?


As a tier 3 medication the cost of Ranexa is quite high; retail costs can be seen in the hundreds. Due to this pricing - since Ranexa is a heart medicine which is used regularly - over time, the cost adds up and can become overwhelming for many. In addition, the generic for Ranexa is not covered by most medicare plans, so even if you buy a generic to save money, you’re likely still going to pay quite a bit for it. However, at our certified online Canadian Pharmacy, you will find affordable prices on both the brand name and the generic alternative which you can purchase with a valid prescription.


How long does Ranexa stay in your system?


Ranexa has a half life of 7 hours; every 7 hours, the amount of medication in your body will decrease by half. Based off Ranexa’s half life, after about 35 hours, the medication should be completely cleared from your system.


Why take Ranexa and isosorbide together?


Anti-anginal medications can range between drug classes of nitrates, calcium antagonists, and beta blockers, with the exception of ranolazine, which does not fall into any of these three categories (since its mechanism of action is unproven). Each drug class has a different mechanism of action; therefore if you use more than 1 type of drug class, you can treat the angina in more than one way, which may ultimately increase efficiency within treatment if a medication isn’t working independently.


When will Ranexa go generic?


A generic for Ranexa is already available for purchase, as of February 2019. The generic for Ranexa is sold under the active ingredients name; ranolazine. We offer both the brand name and the generic alternative at a reduce cost at our certified online Canadian Pharmacy, My Drug Center.

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