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Preparation H Cream is a topical medication consisting of phenylephrine and pramoxine, a sympathomimetic amine and a local aesthetic. We carry this cream in 1% with Bio-Dyne!

Preparation H Cream is used to treat itching, swelling, irritation, and pain caused by hemorrhoids. Hemorrhoids, also known as piles, are veins located in the lower anus and rectum that have become swollen and irritated. Typically hemorrhoids are due to straining during bowel movements, but may also be caused from extended periods of time on the toilet, having chronic diarrhea or constipation, being obese or pregnant, having anal intercourse, and regular heavy lifting. Most times, hemorrhoids are painful and unpleasant, however, they are easy to treat and very preventable!

Preparation H cream is effective at reducing symptoms of hemorrhoids because the sympathomimetic amine is able to narrow the blood vessels in the area of hemorrhoids to decrease swelling and discomfort. The aesthetic works on the nerves in the skin to help block out and reduce the feeling of pain and itching.

Always follow directions given to you by your doctor. Directions can usually be found on the prescription label if you forget.

Before applying the cream, clean the area with mild soap and rinse with water. Ensure the area is completely dry before proceeding. You may apply the cream up to 4 times a day, usually in the morning and bedtime or after each bowel movement.

To apply this product inside the lower part of the anus, use the applicator tip/cap/nozzle provided. When finished, wash your hands thoroughly with warm water and soap.


Do not use Preparation H Cream

Do not use this medical cream if you are allergic to any of its contents. Discuss all drug allergies you have with your doctor before using this cream.

This medication should not be used by children 12 years or younger without the medical advice of a doctor.

Dose adjustment or special precautions may be required

Before using this product, tell your doctor if you have diabetes, heart problems, high blood pressure, overactive thyroid, or if you have difficulties urinating due to a blockage.


It is not known if this drug passes into breast milk or if it will harm a nursing infant. Consult your doctor before breast feeding on this medication.

During pregnancy, this medication should only be used if it is absolutely needed. Before using this cream, go over all the risks and benefits of using this medication while pregnant.

Side Effects

Common side effects of Preparation H Cream may include:

Mild pain/stinging

The above side effects should not alarm you.

Serious side effects of Preparation H Cream may include:

Fast/irregular heartbeat, pounding headache, nervousness, shakiness (tremor), or trouble sleeping.

If you have any of the above side effects, contact your doctor right away.

Contact your doctor if you notice signs of…

allergic reaction: sneezing and an itchy, runny or blocked nose (allergic rhinitis), itchy, red, or watering eyes (conjunctivitis), wheezing, chest tightness, shortness of breath, cough, a raised itchy, red rash (hives) or swollen lips, tongue, eyes or face.


What should I avoid if I am using this product?

Avoid straining when using the bathroom to reduce the chance of hemorrhoids coming back.

What is the best way to store this medication?

Preparation H Cream should be kept at room temperature, stored in a dry place, out of reach of children.

How long until I start feeling relief?

It shouldn’t take very long for relief. If you do not feel relief within a week, contact your doctor.

Does it have any medication interactions?

Yes. Speak with your doctor to get a complete list of drugs that interact with Preparation H Cream. Some drugs that interact with this medication include MAO inhibitors (isocarboxazid, linezolid, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, tranylcypromine), drugs to treat high blood pressure (including guanethidine, beta blockers such as metoprolol).

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