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Known as Premique internationally


What is Prempro used for?

This medication provides hormone replacement therapy. During menopause, a woman's ovaries stop producing the hormones estrogen and progesterone. Menopause is the time in a woman's life when her period stops. Patients often buy Prempro is used to treat menopause symptoms such as hot flashes and vaginal changes and to prevent osteoporosis (bone loss). The prescribed Prempro dosage can make up for the lower amount of estrogen. Patients also buy Prempro to replace estrogen when they have an ovarian failure or other conditions that cause a lack of natural estrogen in the body.


How does Prempro work?

Prempro comes as a tablet for oral administration. The active ingredients of Prempro are conjugated Estrogens (a mixture of Estrogens) and progesterone called Medroxyprogesterone. Estrogen is a female sex hormone produced by the ovaries; estrogen is necessary for many processes in the body. Conjugated estrogens are a mixture of estrogen hormones. Medroxyprogesterone mimics the actions of your own progesterone and regulates ovulation and menstruation.

Before taking your prescribed medication, read all the instructions that were provided by your pharmacist. Take Prempro orally once a day with a full glass of water. This medication can be taken with or without a meal. Make sure you take Prempro at the same time each day to create a routine for yourself and to ensure an even spread of the Conjugated estrogen/Medroxyprogesterone dosage in your system. For optimal results, take this medication on a regular basis. Do not change or increase your dose. You should continue taking this medication even if you feel well. 


This medication may contain medical and non medical ingredients that could cause an allergic reaction. Consult with your doctor about any known allergies before taking Prempro. Speak with your doctor about any known medical conditions relating to vaginal bleeding, blood clots, stroke, heart disease, liver disease, kidney disease, swelling disorders, high blood pressure, diabetes, high blood cholesterol, obesity, lupus, underactive thyroid, mineral imbalance, hormone problems, uterus problems, gallbladder disease, asthma, seizure, migraine headaches, and mental/mood disorders. Tell your doctor about any current medications or supplementation to avoid interactions with Prempro.

Smoking tobacco can increase the risk of stroke, blood clots, high blood pressure, and heart attack in woman over 35 who take Prempro.

Before taking Prempro speak with your doctor if you are bed ridden or have recently had surgery. Being sedentary for extended periods can increase the risk of blood clots.

While taking Prempro you may develop problems wearing your contact lenses. Speak with your eye doctor if vision problems occur during your treatment with Prempro.

Prempro can cause dark patches on your skin (melasma), and direct sunlight and exasperate this effect.  Limit sun exposure, tanning booths, and heat lamps. Wear protective clothing in the sun and wear sunscreen on unprotected areas to avoid discolorations n your skin. 

Side Effects

Some Prempro side effects include: stomach upset or pain, nausea, vomiting, bloating, breast tenderness/pain/swelling, headache, weight or appetite changes, freckles or darkening of facial skin, acne, increased hair growth, loss of scalp hair, problems with contact lenses, vaginal itching or discharge, changes in your menstrual periods, decreased sex drive, nervousness, dizziness, or tired feeling.

If any side effects of Conjugated Estrogens/Medroxyprogesterone become unmanageable speak with your doctor or pharmacist for help in managing any side effects. For any serious side effects that occur speak with your doctor right away for further treatment options.


Q: What happens if I suddenly stop taking this medication?

A: A relapse in symptoms may occur depending on the severity of the condition, and you may experience side effects. You should speak to your doctor before you stop taking this medication.


Q: What is the best dosage to take for Prempro?

A: Your doctor will be able to determine the best Prempro dosage from the initial diagnosis.


Q: What happens if I miss a dose?

A: You should take the missed dose as soon as you realize you have forgotten. If the missed dose is closer to your next scheduled dose, take the next scheduled dose to avoid overlapping.


Q: What is the best way to store this medication?

A: This medication is stored at room temperature and should be kept away from children and pets. 


Q: How do I dispose of this medication?

A: Do not throw away this medication in wastewater. Some medications can be thrown away in dry waste, and some require a little preparation for disposal. If you are uncertain how to dispose of this medication, speak with your pharmacist to safely dispose of any unwanted or experienced medication.


Q: Is this medication safe to use while pregnant or breastfeeding?

A: You should not take this medication if you pregnant due to the effect it can have on the baby. Consult your doctor to understand the risk of using this medication while breastfeeding.

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