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What is Premarin prescribed for?

This medication provides hormone replacement therapy. During menopause, woman's ovaries stop producing the hormones estrogen and progesterone. Menopause is the time in a woman's life when her period stops. Patients often buy Premarin Vaginal Cream to treat vaginal menopause symptoms such as dryness, burning, irritation, and painful sexual intercourse. The prescribed Premarin Vaginal Cream dosage can make up for the lower amount of estrogen. It may also be prescribed to people with kraurosis vulvae, a rare condition affecting the tissues around the vulva.

How does Premarin work?

Premarin Vaginal Cream works by delivering estrogens directly to the source of the pain, to help rebuild vaginal tissue and make intercourse more comfortable. When estrogen topical cream is inserted into the vagina, it is absorbed by the vaginal tissues. The additional estrogens is what aids in rebuilding vaginal tissue and ease some or all of the vaginal symptoms of menopause.

We currently do not offer a Premarin Vaginal Cream generic.

Before applying your prescribed Premarin Vaginal Cream dosage, read all the instructions that was provided by your pharmacist so you know how to administer the medication. Use the Premarin Vaginal Cream dosage exactly as prescribed by your doctor. Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.

Make sure you apply the Conjugated Estrogens at the same time each day to create a routine for yourself and to ensure an even spread of medication in your system. Premarin Vaginal Cream should applied on a regular basis to have optimal results. You should continue using this medication even if you feel well. 


This medication may contain medical and non medical ingredients that could cause an allergic reaction. Consult with your doctor about any known allergies before taking Premarin Cream. Speak with your doctor about any known medical conditions relating to vaginal bleeding, certain cancers, blood clots, stroke, heart disease, swelling disorders, high blood pressure, diabetes, high cholesterol, obesity, lupus, under active thyroid, mineral imbalance, hormone problems, uterus problems, gallbladder disease, asthma, seizures, migraine headaches, blood disorders, and mental/mood disorders. Tell your doctor about any current medications or supplementation to avoid interactions with Premarin Cream.

Smoking tobacco can increase the risk of stroke, blood clots, high blood pressure, and heart attack in woman over 35 who take Premarin Cream.

Before taking your Premarin Vaginal Cream dosage, speak with your doctor if you are bed ridden or have recently had surgery. Being sedentary for extended periods can increase the risk of blood clots.

You may develop problems wearing your contact lenses which is one of the side effects of Conjugated Estrogens. Speak with your eye doctor if vision problems occur during your treatment.

Premarin Cream can cause dark patches on your skin (melasma), and direct sunlight and exasperate this effect.  Limit sun exposure, tanning booths, and heat lamps. Wear protective clothing in the sun and wear sunscreen on unprotected areas to avoid discolorations in your skin.

Side Effects

Premarin Vaginal Cream side effects are:

Nausea, vomiting, bloating, stomach cramps, breast pain/tenderness/swelling, headache, weight changes, changes in appetite, freckles or darkening of facial skin, increased hair growth, loss of scalp hair, problems with contact lenses, vaginal itching or discharge, changes in your menstrual periods, decreased sex drive, nervousness, dizziness, or tired feeling.

If any Premarin Vaginal Cream side effects become unmanageable speak with your doctor or pharmacist for help in managing the side effects. For any serious side effects of Conjugated estrogens, speak with your doctor right away for further treatment options.


Q: What happens if I suddenly stop taking this medication?

A: There may be a relapse in symptoms as well as side effects. You should speak your doctor before you stop taking this medication.

Q: What is the best dosage to take?

A: The diagnosis with your doctor will be able to determine the best dosage for your treatment. 

Q: What happens if I miss a dose?

A: You should take the missed dose as soon you realize you have forgotten. If the forgotten dose is closer to your next scheduled dose, take the next schedule dose to avoid overlapping in dose.

Q: What is the best way to store this medication?

A: This medication is stored at room temperature, and should be kept away from children and pets. Do not throw away this medication in wastewater. If you are uncertain how to dispose of this medication speak with your pharmacist for help in safely disposing of this medication.

Q: Is this medication safe to use while pregnant or breastfeeding?

A: You should not use this medication if you are pregnant or breastfeeding due to the effects it will have on the child.

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