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What is Mysoline (Primidone) prescribed for?

Seizures happen because of abnormal electrical activity in the brain. At times it may go nearly unnoticed, or in other more severe cases, it may cause unconsciousness and convulsions. Seizures usually come along suddenly, but for how long and how severe can vary.

This medication can be used alone or along with other medications to control seizures. A seizure can cause an assortment of troubles for you. Controlling and reducing seizures lets you go about your daily activities, reduces the risk of harm when you lose consciousness and lessens your risk for a possibly life-threatening condition of frequent, repeated seizures.

Primidone belongs to a class of drugs known as barbiturate anticonvulsants. When this medication is put into effect, it works by controlling the abnormal electrical activity in the brain that occurs during a seizure.

This medication is to be taken by mouth, with or without food. And usually 3 to 4 times a day, or as directed to you by your doctor. If an upset stomach occurs, it is best to then take this medication with food or milk.

You doctor may start this medication with you on a lower dose at bedtime and then gradually increase your dose in order to prevent any side effects, such as dizziness and drowsiness.

Dosage is based on your medical condition, blood levels of primidone, use of other medications to treat seizures, and response to treatment. It may take several weeks to reach the best dose for you.

This medication works best when the amount of drug in your body is kept at a constant level. Therefore, take this drug at evenly spaced intervals.


Before taking this medication, it is best to advise your doctor if you are allergic to Primidone; or to other barbiturates (such as phenobarbital); or to other anti-seizure medications (such as carbamazepine, fosphenytoin, oxcarbazepine, phenytoin); or to any other gold or heavy metal compound; or to any other medications or allergies in general.

Before taking this medication, it is for the best to inform you doctor of you Medical history. Especially of;  certain hormone problems (adrenal disease such as Addison's disease), kidney problems, liver problems, lung disease (such as sleep apnea, chronic obstructive pulmonary disease-COPD), mental/mood disorders (such as depression, thoughts of suicide), personal or family history of a substance use disorder (such as overuse of or addiction to drugs/alcohol), personal/family history of a certain blood disorder (porphyria), certain vitamin deficiencies (folic acid, vitamin K).

Side Effects

Some of these side effects may occur when taking this medication; are as follows; Dizziness, drowsiness, excitation, tiredness, headache, loss of appetite, nausea, or vomiting may occur as your body adjusts to the medication. However, if any of these effects persist or worsen, contact your doctor right away.

Tell your doctor right away if you have any serious side effects, including staggering walk/clumsiness, decreased sexual ability/interest, and double vision.

This medication may cause mouth/lip/throat sores (stomatitis). Tell your doctor if you notice a metallic taste in your mouth. This could be the first sign of stomatitis.

A small number of people who take anticonvulsants for any condition (such as seizure, bipolar disorder, or pain) may experience depression, suicidal thoughts/attempts, or other mental/mood problems. Tell your doctor right away if you or your family/caregiver notice any unusual/sudden changes in your mood, thoughts, or behavior, including signs of depression, suicidal thoughts/attempts, thoughts about harming yourself.

Tell your doctor right away if any of these rare but very serious side effects occur: easy bruising/bleeding, fainting, slow heartbeat, severe tiredness/weakness, pale skin, fast/slow/shallow breathing.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any of the following symptoms of a serious allergic reaction: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, and trouble breathing.


What happens if I suddenly stop taking this medication?

There may be a relapse in symptoms as well as side effects. You should speak your doctor before stop taking this medication.


 What is the best dosage to take?

The diagnosis with your doctor will be able to determine the best dosage for your treatment. Work with your doctor closely for dosage and dosing schedules.


 What happens if I miss a dose?

You should take the missed dose as soon as you realize you have forgotten. If the forgotten dose is closer to your next scheduled dose, take the next scheduled dose to avoid overlapping in the dose.


 What is the best way to store this medication?

This medication is stored at room temperature and should be kept away from children and pets. Do not throw away this medication in the wastebasket. If you are uncertain how to dispose of this medication speak with your pharmacist for help in safely disposing of this medication.

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