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What is Motilium prescribed for?

Motilium is a popular prescription medication used for the relief of symptoms of nausea, vomiting, bloating, and other stomach discomfort after eating. It is also used to treat symptoms caused by other medications, such as the one to treat Parkinson’s disease. You can buy Motilium (Domperidone) at MyDrugCenter, and we also have the Domperidone generic version available.

How does Motilium work?

Motilium comes in tablet form to be taken orally. Each Motilium dosage consists of 10 mg of the active ingredient Domperidone. The Domperidone dosage is what makes Motilium work, and it belongs to a group of medications called dopamine antagonists. This medication causes the muscles at the stomach entrance to tighten and the exit muscles to relax. These actions speed up the process whereby food is passed through the stomach and into the intestine.

Experts say that Motilium has an excellent safety profile for long-term use. Because Motilium minimally penetrates the blood-brain barrier, it does not cause any adverse neurological symptoms when taken in the recommended doses. [1]


  1. [1]  Savio C. Reddymasu, Irfan Soykan, and Richard W. McCallum Domperidone: review of pharmacology and clinical applications in gastroenterology

You should follow the instructions of the doctor who prescribed the Motilium or Domperidone dosage to you. Directions and dosage information can also be found on the pack or leaflet inside the pack. Do not start or stop any medicine without the approval of your doctor or pharmacist first.

You should swallow the Motilium dosage whole with a glass of water. It can be taken with or without food. Motilium should be stored at room temperature away from direct sunlight and heat. Do not store it in the bathroom.


Motilium (Domperidone) may contain medical and non medical ingredients that could cause an allergic reaction. Before taking your Motilium dosage, speak with your doctor about any known allergies and medical conditions relating to kidney disease, heart failure, disease of the pancreas, gallstones. This medication enhances movement in the digestive tract, so it may affect the absorption and action of other medications. Therefore, it is important to tell your doctor of any other medication that you may take. This includes prescription, and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here, tell your doctor about all medications or supplementation you use to avoid interactions and unwanted side effects of Domperidone.

This medication enhances movement in the digestive tract, so it may affect the absorption and action of other medications. Therefore, it is important to tell your doctor of any other prescription or nonprescription medication that you may take.

Side Effects

Motilium side effects include: 

Headache, dizziness, dry mouth, nervousness, flushing, or irritability may occur the first several days as your body adjusts to the medication. Trouble sleeping, stomach cramps, hot flashes and leg cramps

If any of these effects continue or become bothersome, inform your doctor.

More serious Motilium side effects include:

  • Tremors
  • Restlessness
  • Severe muscle spasms
  • Anxiety
  • Trouble swallowing [2]

If you notice other side effects of Domperiodone that are not listed above, notify your doctor or pharmacist immediately.


  1. [2]   HealthLink BC | Domperidone


What happens if I suddenly stop taking this medication?

There may be a relapse in symptoms as well as side effects. You should speak your doctor before stopping taking this medication.

What is the best dosage to take?

The diagnosis with your doctor will be able to determine the best dosage for your treatment. Work with your doctor closely for dosage and dosing schedules.

How long does it take for this medication to become active?

Other factors like diet and exercise can influence how effective the medication is. It can take time to see results, be sure to take the medication regularly to see the best results. Stick to any lifestyle changes you have made to help control your blood sugar levels.

What happens if I miss a dose?

You should take the missed dose as soon you realize you have forgotten. If the forgotten dose is closer to your next scheduled dose, take the next schedule dose to avoid overlapping in dose.

What is the best way to store this medication?

This medication is stored at room temperature, and should be kept away from children and pets. Do not throw away this medication in wastewater. If you are uncertain how to dispose of this medication speak with your pharmacist for help in safely disposing of this medication.

Is this medication safe to use while pregnant or breastfeeding?

Speak with your doctor about the risk associated with using this drug while pregnant. It is uncertain if this drug can pass into the breast milk of nursing mother. Consult your doctor to understand the risk in using this medication while breastfeeding.

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