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What is Methenamine Mandelate prescribed for?

Methenamine is used to prevent and control returning urinary tract infections caused by bacteria.  However, it is not meant to be used for any active infections. You must use other antibiotics first to treat and cure the infection. Then you may use this medication to prevent a comeback.

This medication, Methenamine Mandelate, is an antibiotic that stops the growth of bacteria in the urine. Also, this medication, in combination with other ingredients, helps make the urine acidic.  And when the urine is acidic, Methenamine turns into formaldehyde that kills the bacteria.

Keep in mind this antibiotic is only effective against a bacterial infection in the urinary tract. It will not work on other types of bacterial infections, or against viral infections such as the common cold and the flu. Unnecessary use or misuse can lead to this antibiotic having a decreased effect on any future ailments.

This medication is to be taken by mouth, and follow your doctor’s directions exactly. Remember that your dosage is based on your medical condition, and your response to the treatment.

Methenamine works better if your urine is more acidic. Therefore, your doctor may test the acidity of your urine. And if necessary, you doctor may recommend ways to increase urine acidity. Such as taking vitamin C or drinking cranberry juice, and limiting foods that decrease the acidity such as milk products and most fruits.

For the best effect, make sure to take this medication at evenly spaced times, and remember to continue to take this medicine for the full time it has been prescribed to you. Skipping a dose or discontinuing the medicine to early may allow the bacteria to grow, which may lead to a return of the infection and may result in various side effects.


Before taking this medication, it is best to advise your doctor if you are allergic to Methenamine Mandelate; or to formaldehyde; or to any other medications or allergies in general.

Before taking this medication, it is for the best to inform you doctor of you Medical history. Especially of; kidney problems, liver problems, dehydration.

Side Effects

Some of these side effects may occur when taking this medication; they are as follows; Nausea, vomiting, diarrhea, abdominal cramps, and loss of appetite may occur.  However if any of these effects persist or worsen, contact your doctor right away.

Painful or difficult urination may occur with methenamine, although less often. Report these side effects to your doctor, who may need to lower your dose of methenamine or change your treatment to make your urine less acidic.

Tell your doctor right away if any of these unlikely but serious side effects occur: mouth sores, unusual headache, ringing in the ears, muscle cramps, swelling of the arms/legs.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.


What happens if I suddenly stop taking this medication?

There may be a relapse in symptoms as well as side effects. You should speak your doctor before stop taking this medication.


 What is the best dosage to take?

The diagnosis with your doctor will be able to determine the best dosage for your treatment. Work with your doctor closely for dosage and dosing schedules.


 What happens if I miss a dose?

You should take the missed dose as soon as you realize you have forgotten. If the forgotten dose is closer to your next scheduled dose, take the next scheduled dose to avoid overlapping in the dose.


 What is the best way to store this medication?

This medication is stored at room temperature, and should be kept away from children and pets. Do not throw away this medication in the wastebasket. If you are uncertain how to dispose of this medication, speak with your pharmacist for help in safely disposing of this medication.

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