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What is Malarone (Atovaquone/Proguanil) prescribed for?

This medication is a combo drug, and it contains two medications: Atovaquone and Proguanil. And it is used to prevent and treat malaria, which is a disease spread through a mosquito bite.  The Malaria parasites enter the body through these mosquito bites and then live in body tissues such as red blood cells and the liver.

This medication is used to kill the malaria parasites living inside the tissues. In some cases, your doctor may prescribe another medication along with this one to complete your treatment since both medications may be needed for a full and complete cure and to help prevent your system from going into a relapse.

This medication is to be taken by mouth, with food or a milk based drink (whole milk or even a milkshake) that contains far. If you do perchance vomit within 1 hour of taking this medication, repeat the dose.  However, if you are persistently vomiting, contact your doctor right away.

Swallow the tablet whole, Do not chew on the tablet. Although, if you do have difficulties in swallowing the tablet, crush it and mix it with some condensed milk. Take the mixture right away, do not save any for later.

Remember the dosage prescribed to you is based on your medical condition and your response to the treatment. To prevent illness, take atovaquone/proguanil usually once daily at the same time each day, or as directed by your doctor. Start this medication 1-2 days before you enter the malarious area; continue while in the area and for 7 days after leaving.


Before taking this medication, it is best to advise your doctor if you are allergic to atovaquone or proguanil; or to any other medications or allergies in general.

Also it is best to notify your doctor of your medical history. Inform you doctor if you have had any serious health issues in the past, such as; current diarrhea, current vomiting, kidney problems, liver problems, mental/mood problems, seizures.

Side Effects

Some of these side effects may occur when taking this medication; they are as follows; nausea, vomiting, abdominal pain, headache, diarrhea, weakness, loss of appetite, and dizziness. However if any of these effects persist or worsen, contact your doctor right away.

Tell your doctor right away if you have any serious side effects, including: signs of serious liver problems (such as persistent/severe nausea and vomiting, abdominal pain, unexplained tiredness, dark urine, yellowing eyes/skin), signs of anemia (such as worsening tiredness, rapid breathing, pale skin/lips/nails, fast heartbeat while resting), signs of severe infection (such as high fever, severe chills, body aches, sore throat).

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.


What happens if I suddenly stop taking this medication?

There may be a relapse in symptoms as well as side effects. You should speak your doctor before stop taking this medication.


 What is the best dosage to take?

The diagnosis with your doctor will be able to determine the best dosage for your treatment. Work with your doctor closely for dosage and dosing schedules.


 What happens if I miss a dose?

You should take the missed dose as soon as you realize you have forgotten. If the forgotten dose is closer to your next scheduled dose, take the next schedule dose to avoid overlapping in dose.


 What is the best way to store this medication?

This medication is stored at room temperature and should be kept away from children and pets. Do not throw away this medication in the wastebasket. If you are uncertain how to dispose of this medication speak with your pharmacist for help in safely disposing of this medication.

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