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What is Lotrisone Cream (Clotrimazole/Betamethasone) prescribed for?

This medication is a combination of two drugs, Clotrimazole and Betamethasone.  Lotrisone Cream is used to treat a various of fungal skin infections such as ringworm, athlete’s foot and a jock itch.  

Clotrimazole is an azole antifungal that works by preventing the growth of fungus, while Betamethasone is a strong corticosteroid that helps to reduce the swelling, redness and itching that occurs with the skin infection.

The dosage and length of the treatment varies. It mostly depends on what type of infection is being treated. For example Ringworm and Jock itch are usually treated for 2 weeks. Whereas athlete’s foot is usually treated for 4 weeks.

Do not apply more often or use longer than prescribed. This may increase the risk of side effects.

This medication is to be used on the skin only. Clean and dry the affected area, then apply a thin layer of the medication onto the affected are and gently rub in. This is usually done twice a day, unless directed otherwise by your doctor. After use wash your hands. Do not bandage, wrap, or cover the area unless told to do so. If applying to the groin area, be sure to wear loose fitting clothing afterwards.

Do not apply this medication to the eyes, nose, and mouth or inside the vagina. If you per chance do get this medication within these areas, make sure to flush thoroughly.

Continue to take this medication until the full amount of the prescribed medication is completely finished, even if the symptoms do disappear within a few days after you begin. Discontinuance in taking this medication may result in the form of various side effects.


Before taking this medication, it is best to advise your doctor if you are allergic to clotrimazole or betamethasone; or to other azole antifungals (e.g., ketoconazole) or corticosteroids (e.g., triamcinolone); or to any other medications or allergies in general.

Also it is best to notify your doctor of your medical history. Inform you doctor if you have had any serious health issues in the past, such as; immune system problems, poor blood circulation.

Caution is advised when using this drug in the elderly because they may be more sensitive to the effects of the drug, especially thinning skin.

Side Effects

Some of these side effects may occur when taking this medication, they are as follows; Burning, tingling, dry skin, or stinging may occur. However if any of these effects persist or worsen, contact your doctor right away.

If you are experiencing any of these rare but very serious side effects, seek medical help right away. The side effects are as follows; extreme hair growth, skin thinning/discoloration, acne, stretch marks, "hair bumps" (folliculitis).

Rarely, it is possible this medication will be absorbed from the skin into the bloodstream. This can lead to side effects of too much corticosteroid. These side effects are more likely in children, and in people who use this medication for a long time or over large areas of the skin. Tell your doctor right away if any of the following side effects occur: unusual/extreme tiredness, weight loss, headache, swelling ankles/feet, increased thirst/urination, vision problems.


What happens if I suddenly stop taking this medication?

There may be a relapse in symptoms as well as side effects. You should speak your doctor before stop taking this medication.


 What is the best dosage to take?

The diagnosis with your doctor will be able to determine the best dosage for your treatment. Work with your doctor closely for dosage and dosing schedules.


 What happens if I miss a dose?

You should take the missed dose as soon you realize you have forgotten. If the forgotten dose is closer to your next scheduled dose, take the next schedule dose to avoid overlapping in dose.


 What is the best way to store this medication?

This medication is stored at room temperature, and should be kept away from children and pets. Do not throw away this medication in the wastebasket. If you are uncertain how to dispose of this medication speak with your pharmacist for help in safely disposing of this medication.

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