Kazano, which is also known as Vipdomet internationally, is an oral tablet made up of an antidiabetic combination of alogliptin and metformin. We have the brand choice of this medication available in 12.5mg/1000mg!

Kazano is a medication taken by patients with diabetes type 2 (not for diabetes type 1) to help control blood sugar levels. In a person without diabetes type 2, when their blood sugar levels have increased, the pancreas will produce a natural substance called insulin to help relocate it so it can be used to create energy. A person with diabetes type 2 cannot produce enough insulin to create energy from excess sugar, or their body doesn’t know how to use the insulin correctly. This may lead to damage to the heart, blood vessels and other organs which can result in dialysis, blindness, heart disease or stroke, or kidney failure.

Kazano is effective in treating diabetes type 2 because alogliptin is able to increase the amount of insulin being released and reducing the amount of sugar being created by the liver. This is done by increasing the number of incretins (substances that increase insulin production) in the body. Metformin is effective in aiding the body and its response to using the insulin to ensure the body is using the insulin correctly. It also assists alogliptin in decreasing the amount of sugar made in the liver.

Follow the directions given to you by your doctor; ensure you are following your doctor instructions very carefully.

This medication should be taken with food. Ensure you are following the entire treatment plan including any diet and exercise programs set in plan by your doctor.

If your doctor has prescribed vitamin b12 along with Kazano; make sure to take only the amount your doctor has directed you too.

Store Kazano at room temperature and away from moisture and heat risks.

Do not use Kazano (Alogliptin/Metformin)

You should not use this medication if you have severe kidney disease or diabetic ketoacidosis; consult your doctor about alternative medications.

If you have ever had an allergic reaction to alogliptin or metformin

Dose adjustment or special precautions may be required

It is important to mention to your doctor if you have ever had kidney disease, heart disease, liver disease, pancreatitis, gallstones or alcoholism.

If you are pregnant or breast feeding; it is crucial to tell your doctor because controlling blood sugar during pregnancy is important and your doses may be different during each trimester and if you are breast feeding.

Risks

You risk developing a dangerous build-up of lactic acid in your blood during treatment with Kazano. Watch for signs of this condition (see side effects) and contact emergency services right away if you believe you may have lactic acidosis. The risk is higher in those who have other medical conditions, have a severe infection, chronic alcoholism, or if you are a senior 65 years or older.

During treatment, you may have an increased risk of pancreatitis. Watch for signs of this condition (see side effects) and contact your doctor at once if you feel you may have pancreatitis.

This medication could affect ovulation and lead to a higher risk of pregnancy. To avoid pregnancy, use effective birth control methods; consult your doctor.

Kazano is not approved the use of anyone under the age of 18 years old.

If your doctor has prescribed you a glucagon injection kit incase of severe hypoglycemia; ensure your household member and close friends and relative understand how to properly use it.

Common side effects of Kazano (alogliptin/metformin) may include:

diarrhea, upset stomach; increased blood pressure (severe headache, blurred vision, pounding in your neck or ears); back pain, headache; or cold symptoms such as stuffy nose, sinus pain, sore throat.

The above side effects should not alarm you.

Serious side effects of Kazano (alogliptin/metformin) may include: severe or ongoing pain in your joints; pain or burning when you urinate;

If you have any of the above side effects, contact your doctor right away.

Contact your doctor if you notice signs of…

lactic acidosis – unusual muscle pain, feeling cold, trouble breathing, feeling dizzy, lightheaded, or very weak, stomach pain, vomiting, or slow or irregular heartbeat;

liver problems - nausea, upper stomach pain, tiredness, loss of appetite, dark urine, jaundice (yellowing of the skin or eyes); or

heart failure - shortness of breath (even while lying down), swelling in your legs or feet, rapid weight gain.

What is the average dose for an adult with type 2 diabetes?

The average dose for an adult with type 2 diabetes would be an initial dose of 12.5mg/500mg twice a day. You may increase this dose based on efficacy and tolerability. Do not exceed more than 12.5mg/2000mg in a day.

Is this product safe for children?

This medication is not approved for those under the age of 18 years old.

I am getting a CT scan, should I tell them I am on Kazano beforehand?

You may actually need to temporarily stop using Kazano to get a CT scan. Any type of x-ray or CT scan that involves injecting a dye into your vein may be affected by this drug.

What is Vipdomet?

Vipdomet is Kazano. Sometimes medications have different names depending on the country you’re in, and sometimes will share an international name. Kazano, if bought internationally, might be called Vipdomet, but it is made by the same manufacture and is the same product.