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Indocin CR is a controlled-released oral capsule consisting of a non steroidal anti-inflammatory drug called indomethacin. We carry the generic alternative to this medication in 25mg and 50mg.

Indocin CR can be used for the relief of quite a few different painful conditions. These conditions include… Severe osteoarthritis; a condition that occurs when the tissue (cartilage) protecting your joints slowly wears away and allows the bones to rub together, causing pain, swelling and stiffness. Rheumatoid arthritis; a condition in which your immune system “malfunctions” and instead of helping your body fight infections, it begins to attack the lining of your joints. This condition also causes pain, swelling and stiffness and may also lead to bone loss. Ankylosing spondylitis (autoimmune disease);  Similar to rheumatoid arthritis, autoimmune diseases occur when the immune system begins attacking healthy cells in your body instead of foreign ones. Not only does this condition cause the usual inflammation (pain, swelling and stiffness) but can also cause hair loss, rashes, fever and more. Additionally, Indocin CR can be used to treat shoulder pain caused by bursitis or tendinitis. These conditions occur when a joint is over used, or can be caused by gout or an infection.

Indocin CR (indomethacin) is effective in treating conditions related to the joints because the nonsteroidal anti-inflammatory agent is able to block the body’s natural production of certain substances in the body that cause inflammation to occur, decreasing any swelling and pain, allowing for a quicker healing progress.

Follow all the directions on your prescription bottle. These are the directions given to you by your doctor; ensure you follow their directions very carefully.

Swallow this capsule whole with a glass of water. Do not crush, chew, or break the controlled-release tablets.

If you use this medication for long term, you may need frequent medical tests; consult your doctor about which tests you may need.

Store this medication at room temperature away from heat and moisture.


Indocin CR is a very beneficial medication, however, Indocin CR can result in conditions such as heart attack and stroke, which can be fatal and can occur to anyone using Indocin CR regardless of risk factors prior to using this drug. It is important you do not use Indocin CR before or after a heart bypass surgery.

Rarely, Indocin CR can cause stomach bleeding, which can turn fatal. This may occur suddenly without warning and is more likely to occur in those older in age.

Do not use this medication if you are allergic to indomethacin or any of the in active ingredients found in Indocin CR. If you have ever had an asthma attack or severe allergic reaction after taking an aspirin or another NSAID, you should find an alternate medication as Indocin CR may not be safe for you.

To make sure this medication is safe and effective for your use, make sure to tell your doctor about all other medications you are taking and all medical conditions, including if you have ever had heart disease, high blood pressure, a heart attack, stroke, or blood clot, fluid retention, bleeding problems, stomach ulcers or bleeding, asthma, liver or kidney disease, or if you smoke.

Do not take this medication in the final 3 months of pregnancy; doing so may harm your unborn baby. Tell your doctor if you are pregnant before using this medication.

It may not be safe to breast feed while using this drug, Avoid breast feeding until you have discussed with your doctor the benefits and risks of this drug on an nursing infant.

If you are female; this drug may affect your fertility (ability to have children) temporarily.

This medication should not be given to anyone under the age of 14 years old.

Side Effects

Please note; controlled-release tablets are designed to stay in your system for longer and, because of this, some of the capsule may not dissolve before exiting the body through your stool. If you notice this, it should not concern you; it does not determine the effectiveness of treatment.

Common side effects of Indocin CR (indomethacin) may include:

indigestion, nausea; headache; or dizziness.

The above side effects should not alarm you.

Serious side effects of Indocin CR (indomethacin) may include:

a skin rash, no matter how mild; changes in your vision;

If you have any of the above side effects, contact your doctor right away.

Contact your doctor if you notice signs of…

heart attack or stroke; chest pain spreading to your jaw or shoulder, sudden numbness or weakness on one side of the body, slurred speech, leg swelling, feeling short of breath.

heart problems; swelling, rapid weight gain, feeling short of breath;

liver or pancreas problems; -loss of appetite, upper stomach pain (that may spread to your back), nausea, vomiting, diarrhea, unusual tiredness, itching, flu-like symptoms, dark urine, jaundice (yellowing of the skin or eyes);

stomach bleeding; bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;

kidney problems; little or no urination, swelling in your feet or ankles, feeling tired or short of breath; or

anemia; pale skin, unusual tiredness, feeling light-headed or short of breath, cold hands and feet.


What does the “controlled-release” in Indocin CR mean?

Controlled release means the shell of the capsule has been designed to release certain portions of the drug at a controlled predetermined time, over the duration of the day.  For example, you may need to take an immediate released medication twice a day (to keep the drug level consistent and effective) whereas a controlled or extended released medication you would only need to take one a day because the drug will slowly be released throughout the day and kept a constant level without needing to take another tablet.

Is this medication safe for children?

This medication is safe and effective for children who are at least 14 years old. Anyone younger than 14 is not approved to take Indocin CR (or other forms of Indocin).

What other conditions does this medication help with?

Other conditions Indocin (CR) may help is inducing labor, menstruation pain, and unbearable lower back pain caused by kidney stones.

What can I do to help assist Indocin CR with treating my arthritis?

To help aid this capsule in helping your arthritis, you can practice hot and cold therapy, include the right fatty acids in your diet, try acupuncture and losing weight can significantly help with arthritis.

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