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Glucovance is a combination of two antidiabetic drugs called glyburide and metformin. We carry this medication in 2.5mg/500mg and 5mg/500mg. 

Glucovance is prescribed alongside a proper diet and exercise plan to treat high blood sugar in those with diabetes type 2. Glucovance is not effective in treating diabetes type 1. Having high blood sugar can lead to conditions such as heart disease, heart attack, stroke, nerve damage, eye damage, and skin problems. By controlling blood sugar levels, not only are lowering the risk for these health conditions, but also lowering the symptoms of high blood sugar such as intense thirst or hunger, blurry vision, frequently urinating, and numb/tingly feet.

Glucovance is effective in controlling blood sugar because the glyburide released your bodys natural insulin made in the pancreas and decreasing the amount of sugar that your liver makes. Metformin helps by reducing the amount of sugar created by your liver and absorbed by your stomach and intestines.

Ensure you are only following the directions given to you by your doctor. Your dose will be based on your medical condition and response to treatment.

Glucovance is most commonly taken once or twice a day with food. It is important to drink plenty of fluids during the duration of treatment.

Take this medication regularly to get the most benefit from it.


There are some disease interactions with Glucovance, and should be noted before proceeding to use Glucovance. If you have severe kidney disease, if you also take bosentan (Tracleer), or if you have metabolic acidosis or diabetic ketoacidosis, you may want to consider using an alternative medication due to the likeliness of contradictions.

You may need to temporarily discontinue use of Glucovance if you are in need of an x-ray or CT scan that requires injecting dye into a vein.

Taking this medication may increase your risk of developing a serious condition called lactic acidosis. This condition is a dangerous build-up of lactic acid in your bloodstream. If you believe you have lactic acidosis, contact your doctor right away. You risk for lactic acidosis is increased if you also have other medical conditions, a severe infection, chronic alcoholism, or if you are a senior (65+ yrs).

It is unclear if this medication will harm an unborn baby. Medications similar to Glucovance have caused hyperglycemia and newborn babies when the mother was using the medication during pregnancy. Tell your doctor if you are pregnant or plan on becoming pregnant.

Do not breastfeed while using this medication.

Side Effects

Common side effects of Glucovance (Glyburide/Metformin) may include:

low blood sugar; nausea, diarrhea, upset stomach; or headache.

The above side effects should not alarm you.

Contact your doctor if you notice any of the following signs:

heart problems - swelling, rapid weight gain, feeling short of breath;          

severe hypoglycemia - extreme weakness, blurred vision, sweating, trouble speaking, tremors, stomach pain, confusion, seizure; or

lactic acidosis - unusual muscle pain, trouble breathing, stomach pain, vomiting, irregular heart rate, dizziness, feeling cold, or feeling very weak or tired.

If you have any of the above side effects, contact your doctor right away.


What is the average dose for an adult with Diabetes type 2?

The average dose for an adult with Diabetes type 2 is 1.25mg/250mg once a day. The dose may be increased every 2 weeks.

Will this product affect my fertility?

This product may affect your ovulation during the time you are taking Glucovance. It may make pregnancy easier to achieve.

Is this product safe for kids?

This product is approved for adult use only. Those under 18 should not use Glucovance.

Can I drink alcohol while being treated with Glucovance?

It is recommended that you do not consume alcohol while taking this medication because it can cause bother hyperglycemia (high blood sugar) and hypoglycemia (low blood sugar).

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