This medication should not be used by anyone who:
has undiagnosed, unusual vaginal bleeding; liver disease; has a history of heart attacks, strokes, or blood clots; an increased risk of having blood clots due to a heart problem or a hereditary blood disorder; or a history of hormone-related cancer, breast, uterus/cervix, or vagina cancer.
You may need a dose adjustment or special instructions to follow if you have any of the following conditions; make sure to tell you doctor if you have:
heart disease; liver problems, or jaundice caused by pregnancy or taking hormones; kidney disease; gallbladder disease; asthma; epilepsy or other seizure disorder; migraines; lupus; endometriosis or uterine fibroid tumors; hereditary angioedema; porphyria (a genetic enzyme disorder that causes symptoms affecting the skin or nervous system); a thyroid disorder; or high levels of calcium in your blood.
This medication may increase the risk of blood clots; especially those who have high cholesterol, hypertension, diabetes, are overweight or a smoker.
Estrace should not be used to prevent conditions like heart disease, stroke, or dementia. The conditions may develop while using Estrace.
Breast, uterus, and ovary cancer all become a risk when you begin taking Estrace. Talk with your doctor if this risk concerns you.
Breast milk production may become slower when using Estrace. Mention to your doctor if you are breast feeding.