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What is Durezol Ophthalmic Emulsion (Difluprednate) prescribed for?

Anterior Uveitis affects the middle layer of tissue in the eye wall, that is called the Uvea. Which causes inflammation and swelling that can destroy eye tissue, and that destruction can lead to poor vision or blindness. Normally this medication is used to treat the swelling and pain after any eye surgery. But it can be used to treat a serious eye problem known as endogenous anterior uveitis. This medication belongs to a group of drugs known as corticosteroids. It prevents the release of substances within the body that cause inflammation.

This medication comes in a singular dose of 0.5%. Remember, your dose is based on your medical background and your overall response to the treatment. If your doctor or pharmacist has given you some information in the form of a pamphlet, take the time to read up on this drug, and if you have any questions or concerns regarding this medication, please consult your doctor.

Wash your hands before use. Remove the cap, avoid contamination keep the tip of the container away from contact or from any surface. Tilt your head back and look up towards the ceiling. With one finger pull your lower eye lid down to create a pouch. Apply one drop into the pouch, then gently apply pressure to the inner corner of the eye for about 30 seconds.  This will prevent the medication from dripping out.

Look down  and gently close your eyes for about 1 to 2 minutes. Try not to blink and do not rub the eye. Once finished, wash your hands again to remove any of the remaining medication.

Do not allow the dropper to touch the eye when using.

If you use other drops, wait at least 5 minutes after using this medication, before using your others. And if you wear contact lenses, remove them before using these drops.  You may place your contact lenses back in after 15 minutes.


Before taking this medication, tell your doctor if you are allergic to Difluprednate; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems

Before using this medication, tell your doctor or pharmacist your medical history. Especially if you have had any of the following; current or past eye infection (including viral infections such as herpes simplex keratitis), cataracts, glaucoma.

After application, your vision may become temporarily blurred. Do not drive, use machinery, or do any activity that would require clear vision, until your vision has returned to normal, and you are sure you are capable.

Side Effects

Common side effects of this medication do include the following; Temporary blurred vision.  It is best to speak with your doctor promptly if you are experiencing any of these side effects.

However unlikely, these serious side effects should to brought to you doctor’s attention right way; new or increased eye pain/swelling/discharge/redness, eye pain/discomfort in bright light, vision changes.


What happens if I suddenly stop taking this medication?

There may be a relapse in symptoms as well as side effects. You should speak your doctor before stop taking this medication.


What is the best dosage to take?

The diagnosis with your doctor will be able to determine the best dosage for your treatment. Work with your doctor closely for dosage and dosing schedules.


What happens if I miss a dose?

You should take the missed dose as soon as you realize you have forgotten. If the forgotten dose is closer to your next scheduled dose, take the next schedule dose to avoid overlapping in dose.


What is the best way to store this medication?

This medication is stored at room temperature, and should be kept away from children and pets. Do not throw away this medication in the wastebasket. If you are uncertain how to dispose of this medication speak with your pharmacist for help in safely disposing of this medication.

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