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Known as Sandrena internationally


What is Divigel (Estradiol) prescribed for?

Menopause is the end of a woman’s menstrual cycle. A woman is born with all of her eggs, which are stored in the ovaries. Menopause happens when the ovaries no longer release an egg every month and menstruation is at an end.

Divigel is a female hormone, also known as estrogen. It is absorbed through the skin and enters into the bloodstream.  Normally this medication is used by women in need of help in reducing certain symptoms of menopause, such as hot flashes. These symptoms of menopause are caused by the body itself making less estrogen.

This medication comes in two different strengths such as 0.5mg and 1mg. Remember your dose is based on your medical background and your overall response to the treatment. If your doctor or pharmacist has given you some information in the form of a pamphlet, take the time to read up on this drug, and if you have any questions or concerns regarding this medication, please consult your doctor.

This medication is to be applied to the skin only, once daily, on either the right or left upper thigh. The application surface should only be about 5 to 7 inches.  Make sure to wash your hands and the affected area, and then make sure to dry your hands and the skin area that is affected. Do not apply this medication to red and irritated skin. And make sure to apply this gel at the same time each day.

Use the entire contents of a unit dose package each time it is applied. And to avoid potential skin irritation, this medication should be applied to the right or left upper thigh on alternating days.  Do not apply this medication to the face, breasts or irritated skin or in or around the vagina. Cantact with this gel and the eyes should be avoided.

After the application, the gel should be given time to dry before dressing.  Do not wash the area where the application within 1 hour once it has been put on.


Before taking this medication, inform your doctor if you are allergic to Estradiol; or if you have any other allergies in general.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: a history of heart attack, stroke, or blood clot, a bleeding or blood-clotting disorder, liver disease, abnormal vaginal bleeding, history of an allergic reaction to estradiol topical, or a hormone-related cancer such as breast or uterine cancer.

Estradiol may increase your risk of developing a condition that may lead to uterine cancer. Call your doctor at once if you have any unusual vaginal bleeding while using Divigel.

Side Effects

Common side effects of this medication do include the following; breast pain, headache, viginal itching and discharge, changes in menstrual periods, light bleeding or spotting, thinning scalp hair, nausea, vomiting, bloating, and stomach cramps.  It is best to speak with your doctor promptly if you are experiencing any of these side effects.

However, seek medical attention right away if you are experiencing any of the following;  hives, difficulty breathing, swelling of face, lips, tongue, and throat.

Stop using this medication and call you doctor if you; abnormal vaginal bleeding, lump in your breast, confusion, problems with memory, heart attack symptoms, liver problems, signs of a stroke, signs of blood clot in the lungs or legs.


What happens if I suddenly stop taking this medication?

There may be a relapse in symptoms as well as side effects. You should speak your doctor before stop taking this medication.


What is the best dosage to take?

The diagnosis with your doctor will be able to determine the best dosage for your treatment. Work with your doctor closely for dosage and dosing schedules.


What happens if I miss a dose?

You should take the missed dose as soon you realize you have forgotten. If the forgotten dose is closer to your next scheduled dose, take the next schedule dose to avoid overlapping in dose.


What is the best way to store this medication?

This medication is stored at room temperature, and should be kept away from children and pets. Do not throw away this medication in the wastebasket. If you are uncertain how to dispose of this medication speak with your pharmacist for help in safely disposing of this medication.

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