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What is Diclegis (Doxylamine/Pyridoxine) prescribed for?

This medication is a combination drug; it is made of Doxylamine and Pyridoxine. It is used to prevent or reduce the affects of nausea and vomiting caused by pregnancy. And by decreasing these affects, you may improve your health and nutrition during your pregnancy.

Remember your dose is based on your medical background and your overall response to the treatment. If your doctor or pharmacist has given you some information in the form of a pamphlet, take the time to read up on this drug, and if you have any questions or concerns regarding this medication, please consult your doctor.


How does Diclegis (Doxylamine/Pyridoxine) work?

Doxylamine is an antihistamine that is believed to work by affecting certain natural substances, such as acetylcholine and serotonin, but acting directly on certain parts of the brain.  Pyridoxine, on the other hand, is a B vitamin that is important for good health.  And while most people get enough pyridoxine in their diet, certain health conditions, such as pregnancy, can result in the lack of this vitamin.

Take this medication by mouth on an empty stomach, with a glass of water, as directed to you by your doctor. This usually starts with a dose once a day at bedtime.  If your nausea lasts until the next day, notify your doctor and they may direct you to increase your dose to twice daily, once in the morning and once at bedtime. Never take more than 2 tablets a day.

Make sure to swallow the medication whole. Do not crush, chew, split or bite the tablet. Doing so can increase the chances of side effects by releasing all of the medication at once.


Before taking this medication, inform your doctor if you are allergic to doxylamine or pyridoxine; or if you have any other allergies in general.

Before using this medication it is always best to go over your medical history with your doctor, especially if you have had the following; asthma, eye problems (such as glaucoma), stomach problems (such as ulcers, blockage), urination problems (such as urinary retention).

While on this medication, limit alcohol consumption, since this medicine may make you dizzy. Do not do anything hazardous until your vision improves.

Side Effects

Drowsiness, dizziness, or blurred vision may occur. If any of these effects persist or worsen, tell your doctor promptly.

There is some serious side effects to this medication, and if you are encountering any of them, notify your doctor right away. These side effects are listed below;  mental/mood changes (such as confusion, irritability, nervousness), trouble urinating.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.


What happens if I suddenly stop taking this medication?

There may be a relapse in symptoms as well as side effects. You should speak your doctor before stop taking this medication.


What is the best dosage to take?

The diagnosis with your doctor will be able to determine the best dosage for your treatment. Work with your doctor closely for dosage and dosing schedules.


What happens if I miss a dose?

You should take the missed dose as soon you realize you have forgotten. If the forgotten dose is closer to your next scheduled dose, take the next schedule dose to avoid overlapping in dose.


What is the best way to store this medication?

This medication is stored at room temperature, and should be kept away from children and pets. Do not throw away this medication in the wastebasket. If you are uncertain how to dispose of this medication speak with your pharmacist for help in safely disposing of this medication.

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