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Deplin is an oral pill made up of a vitamin/folic-acid-supplement drug called L-methylfolate. We have the generic alternative of this medication in 7.5mg.

L-Methylfolate (folic acid) is a man-made form of folate (a natural form of vitamin B found in certain foods), and is important for the production of red blood cells. This medication is prescribed to those who have low folate levels and risk a lack of red blood cells or anemia, as well as a blood condition called hyperhomocysteinemia. Low folate levels can be caused by diseases (like liver disease), certain medications and/or just not getting enough of it in your diet. Deplin helps to restore the proper amount of folate needed to produce healthy cells, specifically red blood cells.

Do not take more or less of a dose than recommended by your doctor; his or her directions can be found on the prescription bottle; if not, call your health care provider to get the proper instructions.

If your doctor prescribes you the brand specifically, DO NOT buy a generic form. This is the same for if you are prescribed a generic one specifically. It is important to take the exact brand your doctor tells you to when taking Deplin.

You may or may not be directed to take this medication with food.

Avoid crushing, chewing or breaking this tablet; swallow it whole with a full glass of water.

Store at cool room temperature away from light, heat, moisture and children.


Some medical conditions as well as medications to treat those conditions, shouldn’t be mixed with Deplin as they can cause unwanted adverse interactions and sometimes be fatal. Tell your doctor about all past medical conditions as well as all medications you are currently taking, including prescription, over-the-counter, herbal supplements and vitamins, to determine if this medication is right for you.

Your doctor will more specifically ask you the following questions;

Do you have epilepsy or seizures? Do you have a history of vitamin b12 deficiency or pernicious anemia? Have you ever been diagnosed with bipolar disorder/ manic depression?

He/she may also ask if you are planning on becoming pregnant. Your dose may need to be adjusted if you are pregnant or plan to be as well as if you are breastfeeding.

Side Effects

Common side effects of Deplin (L-Methylfolate) may include:

Upset stomach or throwing up. Belly pain; Not hungry; Diarrhea; Feeling sleepy; Headache; or Pimples (acne).

The above side effects should not alarm you.

Serious side effects of Deplin (L-Methylfolate) may include:

A burning or tingling feeling that is not normal; or Swelling.

If you have any of the above side effects, contact your doctor right away.

Signs to watch for:

Allergic Reaction - rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.


What happens if I miss a dose?

Take the missed dose as soon as you remember or skip it if your next dose is approaching soon. Never double up on dosages.

What is the best way to store this medication?

Store at room temperature away from moisture, heat and light. Keep away from children and pets.       

How long does it take for this medication to become active?

Deplin should start working within 1 – 2 weeks.

Does it have any medication interactions?

Warfarin, birth control pills, oral diabetes medicine that contains metformin, NSAIDs (nonsteroidal anti-inflammatory drugs), and seizure medicines are just some of the interactions Deplin may have.

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