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Denavir cream is a topical medication made up of an antiviral drug called penciclovir. This medication can sometimes be referred to as “Vectavir” internationally. Denavir cream usually comes in a dark blue/dark purple/ almost black box and bottle containing a white to pale yellow cream. Appearance can vary depending on if you buy generic or brand name. We have the brand name Denavir cream in 1% bottles.

This medication is used to treat a type of herpes called cold sores. Cold sores are most commonly found on the lips but can also be found on other areas of the face (like the around the eyes) as well as in genital areas. Cold sores are small painful blisters filled with fluid and usually have a clear middle with a thin red ring around them. They often cause pain, tingling, burning and itching.

Penciclovir works to fight cold sores by stopping the growth of the virus. This will allow for a much faster healing process.

Make sure to always follow directions given to you by your healthcare provider. They can usually be found on the prescription label if you forget. Follow these steps for four days or as directed by your doctor. Usually, the cream is applied every 2 hours during the day; you do not need to wake up throughout the night to apply this cream.

1.       Wash your hands and the affected area; this is to prevent the spreading of more bacteria

2.       Apply a thin layer of cream; cover the affected area completely

3.       Rub the cream in; gently until the cream disappears

4.       Wash your hands again; this is to prevent the spreading of more bacteria


Do not use Denavir cream if you are allergic to penciclovir or any other ingredients found in Denavir cream; contents can be found on the Denavir box/bottle.

This medication is for external use only; do not put Denavir cream near your eyes, on open wounds or cuts, in your mouth, nose, or any other opening of the body.

Since Denavir cream is for the skin only and is not absorbed into the body, using the medication is not expected to harm a fetus or nursing infant.

This medication is not for use in children 12 and under.

Side Effects

This product does not usually have a lot of side effects, however if you do experience any side effects and they become bothersome, contact your doctor about alternate medication.

Side effects of Denavir Cream include but are not limited to:

numbness or tingling where the medicine was applied; headache; or changes in your sense of taste.


What if I miss a dose?

Apply the missed dose as soon as you remember, unless your next dose is approaching already, then skip the missed dose.

How do I store this product?

Store in a place away from children at pets at 68°F to 77°F (20°C to 25°C).

How long till I feel relief?

It typically takes about 7 – 10 days for it to completely heal.

Is this cream for all herpes?

This medication is for the treatment of cold sores only and for use on the lips and face only.

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