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Known as Duraprox internationally


Daypro is an oral tablet made up of a nonsteroidal anti-inflammatory drug (NSAID) called oxaprozin. This medication is available for purchase in 600mg tablets.

Oxaprozin, also known as Daypro, is used to treat mild to moderate arthritis. The most common conditions of arthritis that use the treatment of Daypro include osteoarthritis and rheumatoid arthritis. Children (6+) can also use Daypro to fight rheumatoid arthritis.

Oxaprozin works by decreasing the amount of prostaglandins, which are the chemicals accountable for pain, fever and inflammation, by blocking the enzymes, which create prostaglandins.

Your doctor may occasionally change your dose, make sure to follow his instructions very carefully to avoid possibly worsening your conditions, experiencing adverse side effects and to avoid ineffectiveness.

This medication is taken once a day, or as directed by your doctor, with a full glass of water. Avoid lying down for 10 minutes after taking Daypro. If you get a stomachache, take this tablet with food at your next scheduled dose.


Oxaprozin can increase your chance of heart attack or stroke, even if there were not previous risk factors. Do not use day pro prior to or following a coronary artery bypass graft or CABG surgery. Daypro in some cases has also caused stomach bleeding as well as intestinal bleeding, both of which can turn fatal.

Do not use Daypro in the last 3 months of pregnancy; harm to the baby is a risk.

It may also not be safe to breast feed. Talk to your doctor if you have a nursing infant.

This medication is not approved for those under the age of 6 years old.

If you have active bleeding in either your stomach or intestines, or if you have a history of asthma attacks or have had a severe allergic reaction to aspirin (or other NSAIDs) Daypro is not for you; do not take Daypro.

Some medical conditions as well as medications to treat those conditions shouldn’t be mixed with Oxaprozin as they can cause unwanted adverse interactions and sometimes be fatal. Tell your doctor about all past medical conditions as well as all medications you are currently taking including prescription, over the counter, herbal supplements and vitamins, to determine if this medication is right for you. You may need a dose adjustment, extra medication, or to use extra pre caution while on Daraprim if the following apply to you; make sure too tell your doctor if you have or have had:

heart disease, high blood pressure, high cholesterol, diabetes, or if you smoke; a heart attack, stroke, or blood clot; liver or kidney disease; or fluid retention.

Side Effects

Common side effects of Daypro may include:

nausea, upset stomach; or diarrhea, constipation; 

The above side effects should not alarm you.

Serious side effects of Daypro may include:

a skin rash, no matter how mild;

If you have any of the above side effects, contact your doctor right away.

Signs to watch for:

heart problems--swelling, rapid weight gain, feeling short of breath;

stomach bleeding--bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;

liver problems--nausea, upper stomach pain, itching, tired feeling, flu-like symptoms, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);

kidney problems--little or no urination, swelling in your feet or ankles, feeling tired or short of breath; or

low red blood cells (anemia)--pale skin, unusual tiredness, feeling light-headed or short of breath, cold hands and feet.

If you notice any of the above signs, contact your doctor right away


How long until this medication has full effect?

It could take up to 2 weeks until you notice the full benefits (assuming you are taking it regularly).

What is my dose based on?

Your dose is based on body weight (especially in adolescents and children), medical condition, and response to treatment.

Is this medication safe for children?

Yes! It is safe for children who are at least 6 years old.

What are some products that interact with Daypro?

Products that may have a reaction to Daypro include aliskiren; ACE inhibitors such as captopril and lisinopril; angiotensin II receptor blockers such as losartan and valsartan; cidofovir; lithium; methotrexate; and diuretics such as furosemide.

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