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What is CombiPatch (Estradiol/Norethindrone) prescribed for?

This medication is a combination of two female hormones: an estrogen (Esterdoil) and a progestin (norethindrone). It is a medication for woman, used to help reduce the symptoms of menopause, such as hot flashes and vaginal dryness. These symptoms are caused by the body making less estrogen.

This is where the progestin in this medication comes into play. It helps reduce the risk of cancer in the uterus which can be caused by it using estrogen.

This medication should not be used by women you have had their uterus remove, since they do not need progestin, and therefore should not be using this medication. This medication may also be used by women who are unable to produce enough estrogen due to, for example, a primary ovarian failure.

This medication comes in two doses, which are 0.05mg/0.14mg and 0.05mg/0.25mg . Remember your dose is based on your medical background and your overall response to the treatment. If your doctor or pharmacist has given you some information in the form of a pamphlet, take the time to read up on this drug, and if you have any questions or concerns regarding this medication, please consult your doctor.

To begin, peel off the back of the patch, than apply the patch a clean, dry area of the lower stomach. Press firmly for about 10 seconds to assure that it stays on.  Do not apply the patch to the breast or on oil, broke, and irritated skin. And it is best to avoid placing the path where it can easily come off, such as a waistline. Make note that when wearing the patch; do not expose it to the sun for long periods of time.

It is important to use this medication as directed by your doctor, make sure to follow the dosing schedule they have given you very carefully. The patch is usually replaced twice a week.  When reapplying the patch make sure to apply it in a different area then the last spot. Wait at least 1 week before applying patch in the same area, and once used, throw the patch away.  Do not wear 2 patches at the same time.


Before taking this medication, inform your doctor if you are allergic to either Estradiol or Norethindrone; or if you have any other allergies in general.

Before using this medication it is always best to go over your medical history with your doctor, especially if you have had the following;  vaginal bleeding of unknown cause, certain cancers (such as breast cancer, cancer of the uterus/ovaries), blood clots, stroke, heart disease (such as heart attack), liver disease, kidney disease, family medical history (especially breast lumps, cancer, blood clots), family or personal history of a certain swelling disorder (angioedema), blood clotting disorders (such as protein C or protein S deficiency), high blood pressure, diabetes, high blood cholesterol/triglyceride levels, obesity, lupus, underactive thyroid (hypothyroidism), mineral imbalance (low or high level of calcium in the blood), a certain hormone problem (hypoparathyroidism), uterus problems (such as fibroids, endometriosis), gallbladder disease, asthma, seizures, migraine headaches, a certain blood disorder (porphyria), mental/mood disorders (such as dementia, depression).

Do not smoke while on this medication. Estrogens, combined with smoking can further increase your risk of stroke, blood clots, high blood pressure. And heart attack. Especially, in women older than the age of 35.

Using this medication may cause blotchy, dark areas on your face and skin. Sunlight may worsen the effect, so it is best to limit the time you spend outside in the sun. Avoid sun tanning boths and sunlamps.  Make sure to wear protective clothing and wear sunscreen when you are in the outdoors.

Side Effects

Skin redness/irritation at the application site, abdominal pain, nausea/vomiting, bloating, breast tenderness, headache, back pain, or weight changes may occur. If any of these effects persist or worsen, tell your doctor promptly.

There is some serious side effects to this medication, and if you are encountering any of them, notify your doctor right away. These side effects are listed below; mental/mood changes (such as depression, memory loss), breast lumps, unusual vaginal bleeding (such as spotting, breakthrough bleeding, prolonged/recurrent bleeding), increased or new vaginal irritation/itching/odor/discharge, severe stomach/abdominal pain, persistent nausea/vomiting, yellowing eyes/skin, dark urine, swelling hands/ankles/feet, increased thirst/urination.

A very serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction may include: symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

If you are experiencing any of the following, then you need to seek medical attention right away; chest/jaw/left arm pain, unusual sweating, sudden/severe headache, weakness on one side of the body, confusion, slurred speech, sudden vision changes (such as partial/complete blindness), pain/redness/swelling of legs, tingling/weakness/numbness in the arms/legs, trouble breathing, coughing up blood, sudden dizziness/fainting.


What happens if I suddenly stop taking this medication?

There may be a relapse in symptoms as well as side effects. You should speak your doctor before stop taking this medication.


What is the best dosage to take?

The diagnosis with your doctor will be able to determine the best dosage for your treatment. Work with your doctor closely for dosage and dosing schedules.


What happens if I miss a dose?

You should take the missed dose as soon you realize you have forgotten. If the forgotten dose is closer to your next scheduled dose, take the next schedule dose to avoid overlapping in dose.


What is the best way to store this medication?

This medication is stored at room temperature, and should be kept away from children and pets. Do not throw away this medication in the wastebasket. If you are uncertain how to dispose of this medication speak with your pharmacist for help in safely disposing of this medication.

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