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Canasa Suppository is a medication that is used rectally and consists of mesalamine. This is a 5-aminosalicylates class drug and is available in three strengths; 250mg, 500mg, and 1000mg.

Canasa Suppository is most commonly used to treat a bowel disease called ulcerative proctitis. Unfortunately, it is not a cure for this disease but helps combat the symptoms it causes. The symptoms of ulcerative proctitis that Canasa Suppository decrease include frequent defecation, mucus/blood in the stool, irritation and/or swelling of the colon/rectum and the bleeding it causes. This medication is also used to treat ulcerative colitis, proctosigmoiditis, and others not listed here.

Mesalamine (the active ingredient in Canasa) works by blocking out the action of the natural substances located in your body that cause pain and swelling.

Always follow directions given to you by your doctor. Instructions can usually also be found on the prescription or prescription bottle/container.

Always shake the bottle before using.

Avoid holding the suppository for too long before inserting as it can melt in your hand.

Always wash your hands before proceeding with the medicine.

There should no (or very little) discomfort while using this medicine.

How to use Canasa Suppository

  1. Remove wrapper

  2. Lie on your back; knees up towards your chest

  3. Gently insert the suppository into your rectum with the pointed tip first; 1 inch in

  4. Remain laying down for 2 – 3 minutes to ensure the medication melts


If you have severe stomach pain, bloody diarrhea, or cramping contact your doctor right away. This could also occur along with fever, headache and skin rash.

Tell your doctor about all medications you are currently taking including prescription, over-the-counter, vitamins, and herbal remedies. Also be sure to mention any drug allergies you may have.

It is unknown if this medication passes into breast milk or if it will harm and unborn baby. Consult your doctor if you are breastfeeding or pregnant.

Important diseases to tell your doctor consists of:

asthma or sulfite allergy; kidney disease; or liver disease.

Mention it to your doctor even if you no longer have the condition.

Side Effects

Side effects are not always present in everyone. Others are more sensitive to side effects while they could be mild for others. If side effects ever become too much to handle, contact your doctor right away.

Common side effects of mesalamine may include:

stomach pain, nausea, gas;

fever, cold or flu symptoms;

rash; or

feeling tired.

Serious side effects of mesalamine may include:

severe stomach pain,

cramping, and

bloody diarrhea

these side effects may be accompanied by fever, headache and skin rash)

Signs to watch for:

Allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.


What happens if I miss dose?

If you forget to take a dose, just skip it. Take your next dose as you normally would; do not double up on doses.

How long does it take for this medication to work?

It could take up to 3 weeks before you see improvement. If you don’t have symptom relief by week 3, contact your doctor.

Can I mix this medication into a liquid and take it orally?

No! Do not take this medication by mouth. It is distinctly meant for rectum administration.

When is the best time to take this medication?

The best time to take Canasa Suppository would be bedtime. Also, try to empty your bladder and bowels before proceeding.

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