Before taking this medication, notify your doctor if you are allergic to Rosiglitazone or Metformin, or to any other glitazones such as pioglitazone, as well as any other allergies you may have.
Your medical history is something you should relay to your doctor, especially if you have or have had the following; Kidney and liver disease, breathing problems (such as obstructive lung disease, severe asthma) heart disease, blood problems, fluid in the lungs, eye problems, and bone problems.
You may experience blurred vision, dizziness, or drowsiness due to extremely low or high blood sugar. Do not drive, use machinery, or do any activity that requires alertness or clear vision until you are sure you can perform such activities safely.
Limit alcohol while taking this medication because it can increase your risk of developing low blood sugar.
High fever, "water pills" (diuretics such as hydrochlorothiazide), too much sweating, diarrhea, or vomiting may cause loss of too much body water (dehydration) and increase your risk of lactic acidosis. Stop taking this medication and tell your doctor right away if you have prolonged diarrhea or vomiting. Be sure to drink enough fluids to prevent dehydration unless your doctor directs you otherwise.
It may be harder to control your blood sugar when your body is stressed (such as due to fever, infection, injury, or surgery). Consult your doctor because this may require a change in your treatment plan, medications, or blood sugar testing.
This medication may increase the risk of bone fracture (usually in the upper arm, hand, or foot), especially in women. See also Notes section.
Older adults may be more sensitive to the side effects of this medication, especially low blood sugar and lactic acidosis.