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What is Avalide (Irbesartan/Hydrochlorothiazide) prescribed for?

High blood pressure is the measure of the force of blood pushing against blood vessel walls. Hypertension is dangerous because it makes the heart work harder to pump blood out to the body and contributes to the hardening of arteries, stroke, kidney disease and to heart failure.

This medication is a combination of 2 drugs, Irbesartan and Hydrochlorothiazide.  This medication’s uses for treatment are for lowering high blood pressure, helping to prevent strokes, heart attacks, and kidney problems.

Irbesartan is an angiotensin receptor blocker.  It works by relaxing the blood vessels, so that the blood may flow more easily. Hydrochlorothiazide is what is known as a “water pill’, and causes the patient to make more urine, which helps your body get rid of extra salt and water.

Take this medication by mouth, as directed by your doctor.  It is usually taken once daily, with or without food. If this medication causes you to urinate more frequently, it is best to take it at least 4 hours before your bedtime to prevent having to get up and to go to the washroom.

If you are using this medication alongside drugs that lower your cholesterol, take Avalide at least 4 hours before or at least 4 to 6 hours after these medications.

Keep in mind that this dosage is based on your medical condition and response to the treatment. Speak with your doctor if your condition does not improve or worsens.


Before taking this medication, tell your doctor or pharmacist if you are allergic to irbesartan or hydrochlorothiazide; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems.

Before taking this medication, please inform your doctor of your medical history, especially you have experience with what is listed; gout, kidney and liver disease, lupus, dehydration, and skin cancer.

Severe sweating, diarrhea, or vomiting can increase the risk for lightheadedness or a serious loss of body water (dehydration). Report prolonged diarrhea or vomiting to your doctor. To prevent dehydration, drink plenty of fluids unless your doctor directs you otherwise.

 If you have diabetes, this product may affect your blood sugar. Check your blood sugar regularly as directed and share the results with your doctor. Your doctor may need to adjust your diabetes medication, exercise program, or diet.

Side Effects

Dizziness, light headedness, or upset stomach may occur as your body adjusts to the medication. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

This product may cause a loss of too much body water (dehydration) and salt/minerals. Tell your doctor right away if you have any symptoms of dehydration or mineral loss, including: extreme thirst, very dry mouth, muscle cramps/weakness, fast/slow/irregular heartbeat, confusion.

Tell your doctor right away if any of these unlikely but serious side effects occur: fainting, decrease in vision, eye pain, symptoms of a high potassium blood level (such as muscle weakness, slow/irregular heartbeat), signs of kidney problems (such as change in the amount of urine).


 What happens if I suddenly stop taking this medication?

There may be a relapse in symptoms as well as side effects. You should speak your doctor before stop taking this medication.


What is the best dosage to take?

The diagnosis with your doctor will be able to determine the best dosage for your treatment. Work with your doctor closely for dosage and dosing schedules.


What happens if I miss a dose?

You should take the missed dose as soon you realize you have forgotten. If the forgotten dose is closer to your next scheduled dose, take the next schedule dose to avoid overlapping in dose.


What is the best way to store this medication?

This medication is stored at room temperature and should be kept away from children and pets. Do not throw away this medication in the wastebasket. If you are uncertain how to dispose of this medication speak with your pharmacist for help in safely disposing of this medication.


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