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What is Arixtra (Fondaparinux) prescribed for?

The active ingredient in Arixtra is called Fondaparinux, and it is used to treat serious blood clots in legs and lungs. Usually, it is used with another blood thinner medication.

If left untreated, blood clots can travel to the lungs, heart and brain, causing serious breathing problems, heart attack or stroke.  This medication may also be used to prevent any future blood clots after surgeries, that may increase the risk of blood clots. (Surgeries such as hip fracture, abdominal, knee/hip replacement).

This medication is an injection under the skin of the stomach as directed by your doctor.  Do not inject into a muscle. The dosage of the treatment, as well as its length, are based on your medical condition and your response to the treatment.  Keep in mind the dosage may also be based on your weight. You must use this medication on a regular basis to gain the most benefit.

If you are using this medication at home, make sure to learn all preparations and usage from your doctor and health care package provided for you.  Before using, always visually check the product for any particles or discoloration. If either is present, do not use the liquid. Do not mix any other medication with the same injection.

Before injecting a dose, make sure to clean the area where you will be injecting yourself, with rubbing alcohol.  Also change the injection area each time to lessen the injury upon your skin. This medication may also be given to you by a medical professional.


Before using Arixtra, let your doctor know if you are allergic to fondaparinux.  Also notify them of any other allergies you may have.  This product may contain inactive ingredients such as dry natural rubber or latex in the needle cover on the prefilled syringe, which may cause an allergic reaction or other problems.

Also please notify you doctor of you medical history, especially if it includes the following; infection of the heart (bacterial endorcaritis), current serious bleed (bleeding ulcer), low platelet count because of a antiplatelet antibody, bleeding or blood problems,  past blood clotting problems such as herparin, a certain eye problem (diabetic retinopathy), high blood pressure, kidney disease, seizures, stomach/intestinal problems, stroke, recent spinal procedures or puncture, spin problems, recent surgary (especially on the eye, brain or spin, low body weight (less than 50 kilograms/110 pounds)

Limit alcohol while taking this drug because it may increase the risk of stomach bleeding, and Older adults may be more sensitive to the side effects of this drug, especially bleeding.

Side Effects

Pain, bruising, redness, and swelling at the injection site may occur. Headache, nausea, vomiting, swelling of the hands/feet, or fever may also occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Tell your doctor right away if you have any serious side effects, including: easy bleeding/bruising, dark urine, yellow eyes/skin.

This medication may rarely cause serious bleeding. (See also Warning section.) Tell your doctor right away if you have any signs of serious bleeding, including: shortness of breath, coughing up blood, chest pain, cold/blue fingers or toes, unusual dizziness, fainting, fast/irregular heartbeat, joint/muscle pain, mental/mood changes (such as confusion), numbness/tingling, severe stomach/abdominal pain, bloody/black/tarry stools, red/pinkish urine, vomit that looks like coffee grounds.

Get medical help right away if you have any very serious side effects, including: vision problems, weakness on one side of the body, slurred speech, seizures, difficulty moving, severe/persistent headache.


 What happens if I suddenly stop taking this medication?

There may be a relapse in symptoms as well as side effects. You should speak your doctor before stop taking this medication.


What is the best dosage to take?

The diagnosis with your doctor will be able to determine the best dosage for your treatment. Work with your doctor closely for dosage and dosing schedules.


What happens if I miss a dose?

You should take the missed dose as soon you realize you have forgotten. If the forgotten dose is closer to your next scheduled dose, take the next schedule dose to avoid overlapping in dose.


What is the best way to store this medication?

This medication is stored at room temperature, and should be kept away from children and pets. Do not throw away this medication in the wastebasket. If you are uncertain how to dispose of this medication speak with your pharmacist for help in safely disposing of this medication.

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