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Actoplus Met is an oral tablet made up of a combination of thiazolidinediones and biguanide containing anti-diabetic medication used to treat type 2 diabetes. This medication is available in 15MG/850MG in both the brand name Actoplus and the generic as Pioglitazone/Metformin (the two active ingredients in Actoplus Met).

Patients that suffer type two diabetes have too much blood sugar, which causes unwanted symptoms such as having to urinate a lot, being cranky, fatigue, weight loss and increased risk of infections. Actoplus works by lowering the blood sugar levels, decreasing the symptoms of type 2 diabetes.

Follow directions given by your doctor

Swallow tablet, do NOT chew. Store in room temperature. It is typically recommended that you take this medication with water and a meal. If you believe you are feeling better, do NOT stop taking Actoplus Met. Make an appointment with your doctor and he can help decide if you no longer need it. Do not double your dosages if a dosage is missed.


Talk with your doctor before you drink alcohol. Tell your doctor if you have liver disease. Metformin may cause an acid health problem (lactic acidosis), it is a higher chance in elderly people, however overall it is very uncommon Do not take Actoplus Met if you have a very bad infection, low oxygen, or a lot of fluid loss (dehydration). The chance of getting bladder cancer may be raised when taking Actoplus Met. Be careful in hot weather or while being active as it could cause dehydration. There are some risks when it comes to taking this medication while pregnant or breastfeeding and should be talked about with your doctor.

Side Effects

Common side effects;

headache nausea vomiting stomach upset diarrhea weakness sore throat muscle pain

Side effects that need medical attention;

Rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat. (Signs of allergic reaction) Bone pain. Feeling very tired or weak. Change in eyesight. Pain when passing urine or blood in urine. Passing urine more often. Swelling.

This is not a complete list of side effects; ask your doctor for more information on possible side effects


What medications may interact with Actoplus Met?

  • Acetrizoic Acid
  • Diatrizoate
  • Ethiodized Oil
  • Iobenzamic Acid
  • Iobitridol
  • Iocarmic Acid
  • Iocetamic Acid
  • Iodamide
  • Iodipamide

These are just some of the medications that should NOT be taken with Actoplus Met

Is this product safe for children? The elderly?

It is not recommended for use in children as there has not been studies to show the effect on children when using the combination of pioglitazone and metformin.

The elderly may be at higher risk for side effects.

What is the best way to store this medication?

Store in the original container, away from light, moisture, and children in room temperature. Keep lid tightly closed.

What does it look like?

Actoplus Met (Pioglitazone/Metformin) is small and white in color. It comes in tablet form.

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