Buy Activella (Estradiol/Norethindrone) - Brand & Generic

Brand Choice
Generic Choice
Medications orders are filled and shipped from approved fulfillment centers around the world including, but not limited to, Canada, Singapore, United Kingdom, New Zealand, Turkey, Mauritius, India, and Australia. The items in your order may be filled and shipped from any one of the above jurisdictions. The products are sourced from various countries including, but not limited to, Canada, United Kingdom, New Zealand, Turkey, India, and Australia. All of our affiliated fulfillment centers have been approved by the regulatory bodies from their respective countries. All the customer orders are checked and approved by qualified licensed pharmacists.

All trademarks and registered trademarks appearing on this website are the properly of their respective owners and My Drug Center is not affiliated with them in any way.

All generic products listed above are NOT manufactured or authorized by the maker of the brand name product. They are manufactured by licensed generic manufacturers.

Activella, known internationally as Activelle, is a combination of two hormones, estradiol and norethindrone, and is used to treat menopause.  This medication comes in tablet form and is considered an estrogen and progestin (class of drug). It is available in 0.5MG/0.1MG and 1MG/0.5MG. There is no generic alternative available

Other uses include, but are not limited to, treating conditions that arrive before menopause (such as ovaries not producing enough estrogen) and preventing osteoporosis from occurring afterwards. Osteoporosis is a disease where the bone quality and density slowly and silently (usually no symptoms until first fracture is made) become more fragile and porous. Activella helps prevent this disease from occurring. Menopause occurs in females (starting around 40-55 years of age) and is often times accompanied by severe hot flashes and vaginal changes such as dryness, itchiness and burning, all of which Activella is used to treat.

Estradiol (an estrogen) is naturally created in the ovaries, so it helps by making up for what is not produced in woman who cannot produce enough. Estradiol and norethindrone work together to minimize the hot flashes and vaginal changes.

Activella can be taken with or without food. If you take it without food and it causes an upset stomach, take with food for following doses. It is suggested they are taken the same time every day, to help ensure a dose is not missed.

Do not take any more or any less than directed by your doctor.

Treatment of Moderate to Severe Vasomotor Symptoms due to Menopause

One tablet taken daily

1 mg/0.5 mg or;

0.5 mg/0.1 mg

Treatment of Moderate to Severe Symptoms of Vulvar and Vaginal Atrophy due to Menopause

One tablet taken daily

1 mg/0.5 mg

Prevention of Postmenopausal Osteoporosis

One tablet taken daily

1 mg/0.5 mg

0.5 mg/0.1 mg

Tell your doctor if have:

-Had an hysterectomy, a heart attack, stroke, or blood clot

-Hormone-related cancer, and/or breast, cervix, uterus, or vaginal cancer

-Undiagnosed vaginal bleeding

-Liver disease

-A bleeding disorder

-An upcoming surgery

This medicine can increase your risk of developing heart disease, stroke, cancer of the breast, uterus, or ovaries and could cause dementia.

Activella can slow production of breast milk.

More common

  • Body aches or pain
  • chills or fever
  • cold or flu-like symptoms
  • difficulty breathing
  • headache
  • itching of the vagina or genital area
  • nonmenstrual vaginal bleeding
  • pain during sexual intercourse
  • thick, white vaginal discharge with no odor or with a mild odor
  • unusual tiredness or weakness

Speak to your doctor if any of the following occur

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
  • breast tissue changes or discharge
  • changes in vision
  • chest pain
  • confusion, trouble speaking or understanding
  • dark urine
  • general ill feeling or flu-like symptoms
  • light-colored stools
  • nausea, vomiting
  • pain, swelling, warmth in the leg
  • right upper belly pain
  • severe headaches
  • shortness of breath
  • sudden numbness or weakness of the face, arm or leg
  • trouble walking, dizziness, loss of balance or coordination
  • unusual vaginal bleeding
  • yellowing of the eyes or skin

I am a smoker, can I take Activella?

It is strongly recommended you do not smoke while taking Activella and it increases the chances of blood clots and chances of stroke, more likely in patients 35 years and older.

What are some medications that may interact with Activella?

Listed below are only some of the medications that interact with Activella, speak to your doctor about what other medications you are taking before taking Activella;

  • barbiturates, such as phenobarbital
  • benzodiazepines
  • bosentan
  • bromocriptine
  • carbamazepine
  • cimetidine
  • cyclosporine
  • dantrolene

Is this safe for pregnant woman?

This medication should not be used while pregnant or if you plan to be. Take a pregnancy test or make an appointment with your doctor before taking Activella.

Need Help

Need Help?


Call our CareTeam 7 days a week

IMPORTANT DISCLOSURE: All medical content and news articles on this website are supplied by an independent third party company. While the information can be useful, this website relies on others for its creation and cannot guarantee the accuracy, medical efficacy, or reliability of the information provided. In all circumstances, you should always seek the advice of your physician and/or other qualified health professional(s) for drug, medical condition, or treatment advice. This website does not provide any medical advice. The content provided on this website is not a substitute for professional medical advice, diagnosis or treatment.