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Accolate, also known generically as Zafirlukast, is an oral tablet used to treat and help prevent chronic asthma. It can also be used to help relieve hay fever symptoms (such as sneezing, stuffy nose, and watery eyes). This oral tablet is white to yellow in color and is available in 20mg dosages. This dosage amount is recommended for adults and children above the age of 11 and should be taken twice daily. It must be taken on a daily basis in order to be effective. Eating food within 1 – 2 hours of taking accolate may cause a decrease in results. Elderly users may require an adjustment in dosage as clinical trials show them to be more sensitive to the side effects and have a higher risk of adverse events (unexpected medical problems when using a treatment).
Accolate is part of a class called LRAs (leukotriene receptor antagonists), also known as leukotriene modifiers, antileukotrienes and leukotriene synthesis inhibitors. Leukotrienes are natural substances that are released by cells in your body. These substances will cause your body to produce excess mucus and cause inflammation/swelling in your lungs. This is what happens when one experiences asthma or hay fever. Zafirlukast (the active ingredient in accolate) acts as a bodyguard by blocking out the leukotrienes. Since it works by not allowing the release of leukotrienes, it will not do much to help asthma attacks that have already begun (acute asthma) as the leukotrienes have already been dispersed.
Keep this medicine stored in room temperature (20-25°C (68-77°F)), away from light in an air tight container out of reach of small children. For full effectiveness, take your recommended dose either 2 hours after eating or an hour prior. If a dose is missed, do NOT double up on dosages.
Ages 12 and up: 20MG TWICE DAILY or as directed by your doctor
Swallow the tablet whole
Do not chew or crush this tablet
Do NOT use accolate if you suffer from liver disease or cirrhosis
Refrain from taking accolate if you are breast feeding. Accolate is not harmful to unborn babies but make sure to inform your doctor if you are pregnant or plan to be before taking accolate.
Tell your doctor if you take erythromycin or theophylline, or fluconazole (Diflucan) or if you use blood thinners (such as warfarin, jantoven, or Coumadin). Accolate should be discontinued immediately as mixing these medicines can cause ineffectiveness and/or worsening of the condition.
In very rare cases, taking accolate can cause a rare blood condition called Churg-Strauss syndrome. To avoid this, do not stop taking or reduce your dosage unless instructed otherwise by your provider.
Tell your doctor if you experience rashes, flu like symptoms, numbness of the arms or legs or the sensation of pins and needles, severe sinus pain or congestion, as well as if you are experiencing unusual thoughts or depressed mood.
Please note adults ages 65 and up are more likely to experience higher sensitivity to one or multiple side effects listed above
Avoid any activity or situation that may cause an asthma attack.
Children 5 years plus - 10MG of accolate is safe to take twice a day (or as directed by your doctor).
Children 5 years and under - It is not recommended that children under the age of 5 take accolate unless directed by your doctor.
Call emergency services as soon as possible (911 or poison control).
Some signs of overdoes may include dizziness, vomiting, swollen or cracked lips, stomache pain, warmth or tingling in your face and/or loss of balance or coordination.
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