Comparing Tradjenta and Januvia


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Table of Contents


I. Type 2 Diabetes Symptoms

II. What is Januvia?

III. Side Effects of Januvia

IV. Comparison to Tradjenta

V. So, what’s the Verdict?


Type 2 Diabetes Symptoms

Januvia (sitagliptin) and Tradjenta (linagliptin) are two common medications used to manage type 2 diabetes. Neither of these drugs can cure diabetes but can help regulate serious symptoms. Type 2 diabetes typically occurs slowly over time as blood glucose levels fluctuate irregularly. When the body loses its ability to use glucose in the blood, type 2 diabetes may occur and cause serious complications such as nerve damage, kidney damage, vision loss, and heart disease.

You may not notice the initial signs of diabetes, so people may remain undiagnosed for long periods. Once you start noticing symptoms, type 2 diabetes may be advanced, and treatment is essential. The most common symptoms of type 2 diabetes include:

Frequent urination: The kidneys cannot keep up with the amount of glucose being processed, so you may expel glucose-filled urine several times a day.

Extreme thirst: High blood sugar levels can increase thirst, which is exacerbated by frequent urination.

Increased hunger: When there's too much glucose in the body, you may feel like eating more because the glucose is not being used properly.

Slow-healing wounds: Increased blood sugar narrows blood vessels, restricting nutrients from reaching wounds.

a man drinking out of a water bottle

Getting these symptoms under control is vital for a healthy life and body. So which medication is the best for regulating type 2 diabetes? Read on to learn more about the similarities and differences between Januvia and Tradjenta. 

What is Januvia? 

Januvia is used to treat type 2 diabetes and cannot be used for type 1 diabetes. This type of drug is a dipeptidyl peptidase-4 (DPP-4) inhibitor. The DPP-4 inhibitor is activated when sugar increases after a meal. The drug increases insulin levels and lowers blood sugar. This drug also decreases glucagon, which is a hormone that raises blood sugar.   

When taken properly, Januvia can stabilize insulin levels and prevent dangerous blood sugar fluctuations. At My Drug Center, Januvia is available in oral tablets in 25-, 50-, and 100-milligram doses. Clinical studies have found this drug to be effective in those with type 2 diabetes. In one study, 229 people took Januvia for around six months. Before the trial started, the participants had not taken any diabetes drugs for seven weeks.

At the end of the study, those who took Januvia had on average 0.6 percent lower A1C (glycated hemoglobin) level than when they began taking the drug. Those who took the placebo had a 0.2 percent increase in their A1C levels at the end of the study.

Side Effects of Januvia 

Januvia (sitagliptin) is typically taken once a day, which can help prevent type 2 diabetes symptoms and reduce the chance of side effects. Mild side effects may include:

  • Runny or stuffy nose
  • Headache
  • Upper respiratory infection (sinus infection or common cold)

Serious side effects can occur in rare cases, including:

  • Headache
  • Drowsiness
  • Confusion
  • Dizziness
  • Fast heartbeat
  • Sweating
  • Weakness

a man sweating

Along with these side effects, it is important to keep an eye on your kidney and pancreas health. If you notice you have a painful and swollen belly and unexplained swelling in the legs or ankles, talk to your doctor immediately. 

Comparison to Tradjenta

Both Tradjenta (linagliptin) and Januvia are DPP-4 inhibitors. Therefore, both medications work similarly in the body. Because the medications are so similar, it is up to you and your doctor to determine the right medication for you. To get a better view of the small differences, let's examine each medication's pros and cons.

The pros of Januvia include:

  • Can be taken with or without food
  • Less risk of hypoglycemia (low blood sugar) than other diabetes medications
  • Only one pill a day
  • Unlikely risk of weight gain

The cons Januvia:

  • Lowers A1C levels by less than one percent in clinical trials
  • Not a good option for those with heart failure
  • No generic version
  • May worsen kidney function

yellow pills in a person’s hands

The pros of Tradjenta include:

  • Has few drug interactions
  • Can be taken with or without food
  • Low risk of hypoglycemia
  • Good option if you have liver or kidney issues
  • Unlikely to cause weight gain

The cons of Tradjenta include:

  • No generic version
  • May not lower blood sugar levels more effectively than any other diabetic medications

So, what’s the Verdict?

Before a medication is prescribed, patients need to understand that medications are not a cure-all for type 2 diabetes. They are prescribed in a treatment plan along with a diet and exercise routine. When used in conjunction with healthy lifestyle choices, both medications can improve your type 2 diabetes condition. Talk to your doctor to determine the right drug for your treatment plan.

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