Drug Interactions with Celebrex


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Table of Contents


I. Arthritis & Celebrex

II. Celebrex & Corticosteroids

III. Celebrex & Blood Thinners

IV. Alcohol & Celebrex


Arthritis & Celebrex

Celebrex (celecoxib) is a common nonsteroidal anti-inflammatory drug that relieves arthritis pain. This drug can assist in several arthritis symptoms but is most commonly used for osteoarthritis and rheumatoid arthritis. Celebrex does not cure arthritis but can help you live an active and fulfilling life. Arthritis can significantly impact your everyday activities, so medications like Celebrex are often beneficial to your wellbeing.

Osteoarthritis is the most common type of arthritis and usually occurs in older adults. It is also referred to as degenerative arthritis because the cartilage in joints wears away, and bones begin to rub against bone. This unpleasant condition leads to intense feelings of pain, swelling, and stiffness. Over time, people with osteoarthritis can lose strength and mobility, leading to chronic complications.

two older people walking down a street

Rheumatoid arthritis is slightly different from osteoarthritis. It creates the same painful symptoms but is caused by a disruption in the immune system rather than wear and tear. Rheumatoid arthritis occurs when the immune system mistakenly attacks the joints and creates uncontrolled inflammation. This inflammation may spread to other organs and damage other parts of the body.

Celebrex can significantly improve arthritis symptoms, but it is important to remain aware of any drug interactions that may occur when taking this drug. If you have been living with arthritis for many years, you are likely taking several medications to keep your health in order. Read on to learn more about possible drug interactions that may occur with Celebrex.

Celebrex & Corticosteroids

As mentioned earlier, Celebrex is an NSAID. NSAIDs are a marvel of modern medicine that can treat inflammation and mild to moderate pain. Around 30 million people in the United States use NSAIDs every day to treat headaches, sprains, and arthritis symptoms. Celebrex is a tailored NSAID used for arthritis, but it may still interact with similar drugs that commonly interact with NSAIDs. 

NSAIDs have moderate interactions with corticosteroid medications. Corticosteroids are similar to NSAIDs because they also help lower inflammation in the body. They may also reduce immune system activity. Typically, corticosteroids ease swelling, itching, redness, and allergic reactions. Researchers have found that taking NSAIDs and corticosteroids may increase your risk of developing a bleeding stomach ulcer. You should tell your doctor if you have a history of stomach ulcers before taking Celebrex (celecoxib) and other corticosteroid medications.

Celebrex & Blood Thinners

Around two to three million people take blood thinners every day. Blood thinners allow blood to flow through veins and arteries smoothly. This prevents blood clots from forming and becoming larger, preventing serious cardiovascular problems like heart disease and heart defects.

an animation of a blood clot with a person grabbing their chest in the background

There are several side effects of blood thinners, but the benefits generally outweigh the risks. It is important to know the risks of blood thinners, including an increased risk of bleeding. Many people taking prescription-strength NSAIDs like Celebrex may also be taking blood thinners. NSAIDs have been known to interact with blood thinners, so it is essential to talk to your doctor if you are on blood thinners and may require Celebrex. NSAIDs affect the way blood platelets work and may interfere with normal blood clotting. This could raise your risk of bleeding, especially in the digestive tract.

Alcohol and Celebrex 

Generally, alcohol does not mix well with a majority of prescription drugs. Alcohol has been known to interact adversely with certain arthritis medications like Celebrex (celecoxib). The average adult male should have no more than two drinks a day and one drink a day for women. If you overuse alcohol with NSAIDs, you can significantly increase your risk of gastrointestinal issues, like stomach ulcers.

Stomach ulcers may occur because NSAIDs can irritate the stomach lining. Alcohol has similar effects on the stomach and can further increase the risk. Internal stomach bleeding may occur and cause life-threatening complications. Because of these factors, it may be best to reduce your alcohol intake or stop altogether to prevent stomach issues while taking Celebrex.

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